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Found 724 with Last Name = 'o''neill' and Initial = 'ea'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15241(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataKi:  870nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50194461(7-amino-5-(2,4-difluorophenyl)-1-(2,6-difluorophen...)
Affinity DataKi:  5.10E+3nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317587(6-(2,4-difluorophenyl)-1-(2-fluoro-5-(1,3,4-oxadia...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317588(6-(2,4-difluorophenyl)-1-(2-fluoro-5-(5-methyl-1,3...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50317579(6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2H-q...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122387(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175747(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122386(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122385(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-pipe...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50375790(CHEMBL270004)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122390(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50:  0.130nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219316(CHEMBL545353)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50375797(CHEMBL269792)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222624(CHEMBL357598)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222627(CHEMBL356125)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50375796(CHEMBL255403)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122384(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-(pip...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122379(7-(1-tert-Butyl-piperidin-4-yl)-5-(2-chloro-4-fluo...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175762(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175758(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50375798(CHEMBL437024)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175760(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122382(5-(2-Chloro-4-fluoro-phenyl)-7-[1-(1-cyclopropyl-e...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175758(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421140(CHEMBL2088591)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175761(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222629(CHEMBL142187)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222628(CHEMBL142697)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122377(5-(2-Chloro-4-fluoro-phenyl)-7-(1-cyclobutyl-piper...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175760(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175742(7-(8-aza-bicyclo[3.2.1]octan-3-yl)-5-(2-chloro-4-f...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50375788(CHEMBL257697)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122391(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-(pip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122395(5-(2-Chloro-4-fluoro-phenyl)-7-(1-cyclopropylmethy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122391(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-(pip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122405(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50476040(CHEMBL219796)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175751(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175750(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50375795(CHEMBL403389)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421141(CHEMBL2088578)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421137(CHEMBL2088588)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122389(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 13(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222094(CHEMBL96305)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against mouse Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50222105(CHEMBL92814)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against mouse Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122389(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122376(5-(2-Chloro-4-fluoro-phenyl)-7-(1-cyclobutylmethyl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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