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Found 269 with Last Name = 'oborski' and Initial = 'ce'
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477060(CHEMBL393761)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477067(CHEMBL237875)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477038(CHEMBL237850)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477048(CHEMBL236597)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477051(CHEMBL237666)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485444(CHEMBL2059813)
Affinity DataIC50:  0.178nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477046(CHEMBL236595)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477065(CHEMBL236592)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458169(Avagacestat | BMS 708163 | BMS-708163 | BMS-708163...)
Affinity DataIC50:  0.225nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477022(CHEMBL236594)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477037(CHEMBL237867)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477040(CHEMBL237665)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483746(CHEMBL1770758)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483742(CHEMBL1770898)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483760(CHEMBL1770893)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483743(CHEMBL1770899)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477021(CHEMBL236596)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483743(CHEMBL1770899)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483760(CHEMBL1770893)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477061(CHEMBL393401)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483756(CHEMBL1770885)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477041(CHEMBL393397)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483756(CHEMBL1770885)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485438(CHEMBL2059021)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485443(CHEMBL2059814)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477050(CHEMBL236775)
Affinity DataIC50:  1nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483742(CHEMBL1770898)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477056(CHEMBL236773)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483759(CHEMBL1770760)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477050(CHEMBL236775)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477047(CHEMBL240700)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483759(CHEMBL1770760)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477069(CHEMBL240068)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477057(CHEMBL237669)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483753(CHEMBL1770897)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485431(CHEMBL2059815)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477027(CHEMBL392759)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477052(CHEMBL240066)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477042(CHEMBL236774)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477068(CHEMBL236790)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477055(CHEMBL241350)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483746(CHEMBL1770758)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483755(CHEMBL1770761)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483736(CHEMBL1770888)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477063(CHEMBL393756)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477063(CHEMBL393756)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483754(CHEMBL1770759)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477047(CHEMBL240700)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485434(CHEMBL2059016)
Affinity DataIC50:  2.75nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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