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Found 661 with Last Name = 'ohtani' and Initial = 'm'
TargetProstaglandin-H2 D-isomerase(Homo sapiens (Human))
Shionogi

Curated by PDSP Ki Database
LigandPNGBDBM50008805(7-(3-Benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)...)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin-H2 D-isomerase(GUINEA PIG)
Shionogi

Curated by PDSP Ki Database
LigandPNGBDBM50008805(7-(3-Benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)...)
Affinity DataKi:  0.490nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin-H2 D-isomerase(Homo sapiens (Human))
Shionogi

Curated by PDSP Ki Database
LigandPNGBDBM50060462((Z)-7-{(1R,2R,3S,5S)-2-[(5-Hydroxy-benzo[b]thiophe...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin-H2 D-isomerase(Homo sapiens (Human))
Shionogi

Curated by PDSP Ki Database
LigandPNGBDBM50060462((Z)-7-{(1R,2R,3S,5S)-2-[(5-Hydroxy-benzo[b]thiophe...)
Affinity DataKi:  24.2nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin-H2 D-isomerase(GUINEA PIG)
Shionogi

Curated by PDSP Ki Database
LigandPNGBDBM50060462((Z)-7-{(1R,2R,3S,5S)-2-[(5-Hydroxy-benzo[b]thiophe...)
Affinity DataKi:  193nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin-H2 D-isomerase(Homo sapiens (Human))
Shionogi

Curated by PDSP Ki Database
LigandPNGBDBM85347(BWA868C | CAS_122021 | NSC_122021)
Affinity DataKi:  2.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin-H2 D-isomerase(Homo sapiens (Human))
Shionogi

Curated by PDSP Ki Database
LigandPNGBDBM50008805(7-(3-Benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50060458((Z)-7-[(1R,2S,3S,4S)-3-(Naphthalene-2-sulfonylamin...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of [3H]- (+)-S-145 specific binding to human platelet membranes in TXA2 receptor (TP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50060454((Z)-7-{(1R,2R,3S,5S)-2-[(5-Fluoro-benzo[b]thiophen...)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of [3H]-PGD-2 specific binding to Prostaglandin D2 receptor fromhuman platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50060462((Z)-7-{(1R,2R,3S,5S)-2-[(5-Hydroxy-benzo[b]thiophe...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [3H]-PGD-2 specific binding to Prostaglandin D2 receptor fromhuman platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128750(7-{2-[(5-Fluoro-benzo[b]thiophene-3-carbonyl)-amin...)
Affinity DataIC50:  0.420nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  0.540nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077162((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Affinity DataIC50:  0.650nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128768(7-{2-[(5-Hydroxy-benzo[b]thiophene-3-carbonyl)-ami...)
Affinity DataIC50:  0.900nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50060462((Z)-7-{(1R,2R,3S,5S)-2-[(5-Hydroxy-benzo[b]thiophe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50060453((Z)-7-{(1R,2R,3S,5S)-2-[(6-Hydroxy-benzo[b]thiophe...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of [3H]-PGD-2 specific binding to Prostaglandin D2 receptor fromhuman platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063148((R)-2-(Biphenyl-4-sulfonylamino)-N-hydroxy-3-(1H-i...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053109(CHEMBL331755 | [1-Aminooxalyl-3-(2-benzyl-benzyl)-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053136((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-methyl-indo...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077157((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50085993((E)-N-(((2S,4R)-4-((biphenyl-2-ylmethyl)(isobutyl)...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50060454((Z)-7-{(1R,2R,3S,5S)-2-[(5-Fluoro-benzo[b]thiophen...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128768(7-{2-[(5-Hydroxy-benzo[b]thiophene-3-carbonyl)-ami...)
Affinity DataIC50:  1.90nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50085984(CHEMBL9161 | N-[1-[2-(2,4-Difluoro-benzoyl)-benzoy...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128767(7-{2-[(6-Hydroxy-benzo[b]thiophene-3-carbonyl)-ami...)
Affinity DataIC50:  2.20nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50020743(CHEMBL53346 | Sodium; (+)-7-(3-benzenesulfonylamin...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of thromboxane A2 synthetase from human platelets by 1 uM of the compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063139((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50060453((Z)-7-{(1R,2R,3S,5S)-2-[(6-Hydroxy-benzo[b]thiophe...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053106(CHEMBL120112 | [1-Aminooxalyl-2-ethyl-3-(3-trifluo...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053108((1-Aminooxalyl-3-benzyl-2-methyl-indolizin-8-yloxy...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053102(CHEMBL121245 | [1-Aminooxalyl-3-(3-chloro-benzyl)-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053137((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50085986(CHEMBL267258 | N-{4-(Biphenyl-2-ylmethyl-isobutyl-...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128750(7-{2-[(5-Fluoro-benzo[b]thiophene-3-carbonyl)-amin...)
Affinity DataIC50:  3.20nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077161((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  3.90nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063154((R)-2-{4-[2-(4-Bromo-phenyl)-2H-tetrazol-5-yl]-ben...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053114((1-Aminooxalyl-3-biphenyl-3-ylmethyl-2-ethyl-indol...)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077152((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077155((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077163((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  4.70nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053133((1-Aminooxalyl-3-benzyl-2-ethyl-indolizin-8-yloxy)...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063148((R)-2-(Biphenyl-4-sulfonylamino)-N-hydroxy-3-(1H-i...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053123((1-Aminooxalyl-2-ethyl-3-naphthalen-1-ylmethyl-ind...)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human secretory phospholipase A2 (sPLA2), chromogenic screening assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50053096(CHEMBL123774 | [1-Aminooxalyl-3-(4-butyl-benzyl)-2...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against recombinant human secretory phospholipase A2 (s-PLA2) by phosphatidylcholine/deoxycholate assay (PC/DOC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50085987(4-(2,4-Dioxo-thiazolidin-5-ylidenemethyl)-N-[1-[2-...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of Human cPLA2 alpha using Enzyme assay(PC/DOG assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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