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Found 187 with Last Name = 'ohwada' and Initial = 'j'
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362779(CHEMBL1940181 | US9126931, 346)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362778(CHEMBL1940182)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344664(6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362781(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362782(CHEMBL1940179)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352764(CHEMBL1823220)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362783(CHEMBL1940178)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175003(CHEMBL3808812)
Affinity DataIC50:  7nMAssay Description:Inhibition of human PI3K p110beta/p85alpha expressed in baculovirus preincubated for 20 mins followed by addition of phosphorylate phosphatidylinosit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338198(3-(2-morpholino-7-(pyridin-4-yl)-6,7-dihydro-5H-py...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338198(3-(2-morpholino-7-(pyridin-4-yl)-6,7-dihydro-5H-py...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175020(CHEMBL3810369)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha expressed in baculovirus preincubated for 20 mins followed by addition of phosphorylate phosphatidylinosi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402202(CHEMBL2203964)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352765(CHEMBL1823219)
Affinity DataIC50:  11nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50174998(CHEMBL3808691)
Affinity DataIC50:  13nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha expressed in baculovirus preincubated for 20 mins followed by addition of phosphorylate phosphatidylinosi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338197(5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402204(CHEMBL2203978)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50499395(CHEMBL3735840)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352763(CHEMBL1823222)
Affinity DataIC50:  15nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362780(CHEMBL1940180)
Affinity DataIC50:  16nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175003(CHEMBL3808812)
Affinity DataIC50:  22nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha expressed in baculovirus preincubated for 20 mins followed by addition of phosphorylate phosphatidylinosi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50499397(CHEMBL3734954)
Affinity DataIC50:  25nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50175021(CHEMBL3810395)
Affinity DataIC50:  26nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha expressed in baculovirus preincubated for 20 mins followed by addition of phosphorylate phosphatidylinosi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50425230(CHEMBL2314287)
Affinity DataIC50:  26nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344663(6,6-dimethyl-8-(4-(oxetan-3-yl)piperazin-1-yl)-11-...)
Affinity DataIC50:  27nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50499396(CHEMBL3736189)
Affinity DataIC50:  32nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338199(5-(2-Morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338199(5-(2-Morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338199(5-(2-Morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50338199(5-(2-Morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha expressed in baculovirus preincubated for 20 mins followed by addition of phosphorylate phosphatidylinosi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50499390(CHEMBL3736165)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338197(5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-...)
Affinity DataIC50:  36nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402206(CHEMBL2203976)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50499394(CHEMBL3736509)
Affinity DataIC50:  40nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338200(3-(2-morpholino-7-(pyridin-3-yl)-6,7-dihydro-5H-py...)
Affinity DataIC50:  41nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338200(3-(2-morpholino-7-(pyridin-3-yl)-6,7-dihydro-5H-py...)
Affinity DataIC50:  41nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50499389(CHEMBL3736206)
Affinity DataIC50:  42nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362787(CHEMBL1940174)
Affinity DataIC50:  44nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50499392(CHEMBL3736186)
Affinity DataIC50:  46nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50499393(CHEMBL3735088)
Affinity DataIC50:  48nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by adapta universal kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50425224(CHEMBL2314582)
Affinity DataIC50:  49nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352765(CHEMBL1823219)
Affinity DataIC50:  50nMAssay Description:Inhibition of KIT activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175004(CHEMBL3808686)
Affinity DataIC50:  52nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha expressed in baculovirus preincubated for 20 mins followed by addition of phosphorylate phosphatidylinosi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352765(CHEMBL1823219)
Affinity DataIC50:  61nMAssay Description:Inhibition of KDR activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175023(CHEMBL3810130)
Affinity DataIC50:  64nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha expressed in baculovirus preincubated for 20 mins followed by addition of phosphorylate phosphatidylinosi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352762(CHEMBL1823223)
Affinity DataIC50:  66nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362786(CHEMBL1940175)
Affinity DataIC50:  67nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362784(CHEMBL1940177 | US9126931, 438)
Affinity DataIC50:  69.3nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338196(3-(7-(1H-benzo[d]imidazol-6-yl)-2-morpholino-6,7-d...)
Affinity DataIC50:  77nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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