TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf
Curated by ChEMBL
Helmholtz-Zentrum Dresden-Rossendorf
Curated by ChEMBL
Affinity DataKi: 9nMAssay Description:Competitive inhibition of VEGFR2 by qPCR methodMore data for this Ligand-Target Pair
TargetCysteine proteinase B(Leishmania mexicana)
Universidade De Mogi Das Cruzes (Umc)
Curated by ChEMBL
Universidade De Mogi Das Cruzes (Umc)
Curated by ChEMBL
Affinity DataKi: 2.17E+4nMAssay Description:Inhibition of Leishmania mexicana rCPB2.8 assessed as inhibition constant using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 0.640nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 0.780nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase DNA-dependent DNA polymerase activity by gel-based primer extension assa...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by filter-based filtration assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by filter-based filtration assayMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filte...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins by fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins by fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of Trypanosoma cruzi Cruzain using Z-FR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of DNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by gel-based primer extension assayMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by filter-based filtration assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of RNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase by filter-based filtr...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase DNA-dependent DNA polymerase activity by gel-based primer extension assa...More data for this Ligand-Target Pair
Affinity DataIC50: 101nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 107nMAssay Description:Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filte...More data for this Ligand-Target Pair
Affinity DataIC50: 109nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 112nMAssay Description:Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filter-based filtration assayMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of DNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by gel-based primer extension assayMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filter-based filtration assayMore data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 129nMAssay Description:Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filte...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Mcgill University Aids Centre
Curated by ChEMBL
Mcgill University Aids Centre
Curated by ChEMBL
Affinity DataIC50: 131nMAssay Description:Inhibition of DNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by gel-based primer extension assayMore data for this Ligand-Target Pair
Affinity DataIC50: 131nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair