Affinity DataIC50: 0.0720nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of recombinant human cathepsin K in a fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of recombinant human cathepsin K in a fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human cathepsin K in a fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.710nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.710nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.770nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.830nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.910nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 0.940nMAssay Description:Inhibition of recombinant human cathepsin K in a fluorescence assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Experimental Therapeutics Centre
Curated by ChEMBL
Experimental Therapeutics Centre
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant RET expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human cathepsin K in a fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of cystiene protease cathepsin K of ratMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human cathepsin K in a fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 2.54nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon
Curated by ChEMBL
University Of Oregon
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of recombinant human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Concentration required to inhibit 50% of cysteine protease cathepsin K of humanMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Oregon
Curated by ChEMBL
University Of Oregon
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair