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Found 142 with Last Name = 'orlowski' and Initial = 'm'
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071558(3-Hydroxy-6-methyl-4-[(2S,3S)-3-methyl-2-(2-naphth...)
Affinity DataKi:  50nMAssay Description:Inhibitory activity against plasmepsin-2 from Plasmodium falciparumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071554(3-Hydroxy-4-[(2S,3S)-3-methyl-2-(2-naphthalen-2-yl...)
Affinity DataKi:  50nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071554(3-Hydroxy-4-[(2S,3S)-3-methyl-2-(2-naphthalen-2-yl...)
Affinity DataKi:  90nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071561(3-Hydroxy-4-{(2S,3S)-3-methyl-2-[2-(naphthalen-2-y...)
Affinity DataKi:  110nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071546(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  110nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071555(3-Hydroxy-4-{(2S,3S)-1-hydroxy-3-methyl-2-[2-(naph...)
Affinity DataKi:  180nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071562(3-Hydroxy-4-{(S)-2-[2-(naphthalen-2-yloxy)-acetyla...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071559((S)-2-[2-(Naphthalen-2-yloxy)-acetylamino]-pentane...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071550(CHEMBL74562 | N-[(1S,2S)-1-(1-Benzyl-3-butylcarbam...)
Affinity DataKi:  220nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071556(CHEMBL74943 | N-[(1S,2S)-1-(1-Benzyl-3-butylcarbam...)
Affinity DataKi:  220nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071558(3-Hydroxy-6-methyl-4-[(2S,3S)-3-methyl-2-(2-naphth...)
Affinity DataKi:  320nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071552(1-{[(1S,2S)-1-(1-Benzyl-3-butylcarbamoyl-2-hydroxy...)
Affinity DataKi:  410nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50146770(CHEMBL94646 | N-(1-{1-[1-Hydroxy-2-(3-phenyl-propy...)
Affinity DataKi:  440nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50072543((3S,4S)-4-(2-{1-[4-Amino-3-(4-chloro-phenyl)-butyr...)
Affinity DataKi:  490nMAssay Description:Compound was tested for inhibitory activity against plasmepsin IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071551(CHEMBL427946 | N-[(S)-1-(1-Benzyl-3-butylcarbamoyl...)
Affinity DataKi:  500nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071562(3-Hydroxy-4-{(S)-2-[2-(naphthalen-2-yloxy)-acetyla...)
Affinity DataKi:  560nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071555(3-Hydroxy-4-{(2S,3S)-1-hydroxy-3-methyl-2-[2-(naph...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071549(CHEMBL309056 | N-[(S)-(1-Benzyl-3-butylcarbamoyl-2...)
Affinity DataKi:  590nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071553(1-({(1S,2S)-1-[1-Benzyl-2-hydroxy-3-(3-phenyl-prop...)
Affinity DataKi:  600nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071547(3-Hydroxy-4-{(R)-2-[2-(naphthalen-2-yloxy)-acetyla...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071557(3-Hydroxy-6-methyl-4-{(S)-4-methyl-2-[2-(naphthale...)
Affinity DataKi:  920nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50072545(6-{3-((1S,2S)-1-Benzyl-3-butylcarbamoyl-2-hydroxy-...)
Affinity DataKi:  1.10E+3nMAssay Description:Compound was tested for inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071560(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50146770(CHEMBL94646 | N-(1-{1-[1-Hydroxy-2-(3-phenyl-propy...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071551(CHEMBL427946 | N-[(S)-1-(1-Benzyl-3-butylcarbamoyl...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50072542(4-(2-Phenethyloxy-ethyl)-1-[3-(3,4,5-trimethoxy-ph...)
Affinity DataKi:  1.80E+3nMAssay Description:Compound was tested for inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071550(CHEMBL74562 | N-[(1S,2S)-1-(1-Benzyl-3-butylcarbam...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071553(1-({(1S,2S)-1-[1-Benzyl-2-hydroxy-3-(3-phenyl-prop...)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50072544((3S,4S)-3-Hydroxy-4-{2-[1-(4-isopropoxy-benzoyl)-4...)
Affinity DataKi:  5.30E+3nMAssay Description:Compound was tested for inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071557(3-Hydroxy-6-methyl-4-{(S)-4-methyl-2-[2-(naphthale...)
Affinity DataKi:  5.60E+3nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071546(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  5.80E+3nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071549(CHEMBL309056 | N-[(S)-(1-Benzyl-3-butylcarbamoyl-2...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071549(CHEMBL309056 | N-[(S)-(1-Benzyl-3-butylcarbamoyl-2...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071560(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  1.20E+4nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071547(3-Hydroxy-4-{(R)-2-[2-(naphthalen-2-yloxy)-acetyla...)
Affinity DataKi:  1.50E+4nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071549(CHEMBL309056 | N-[(S)-(1-Benzyl-3-butylcarbamoyl-2...)
Affinity DataKi: >3.00E+4nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071559((S)-2-[2-(Naphthalen-2-yloxy)-acetylamino]-pentane...)
Affinity DataKi: >3.00E+4nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataIC50:  50nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187218((S)-1-(3,4,5-trichloro-2-hydroxyphenylsulfonyl)pyr...)
Affinity DataIC50:  80nMAssay Description:Cytotoxicity against human Huh7 cell line containing HCV genotype 1b repliconMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150374(2-[(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalen...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176486((5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H...)
Affinity DataIC50:  130nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176480((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]th...)
Affinity DataIC50:  140nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176488(((R)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...)
Affinity DataIC50:  170nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176479((5-bromo-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...)
Affinity DataIC50:  190nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187221((4S)-3-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1,...)
Affinity DataIC50:  240nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187232((S)-1-(3-bromo-5-chloro-2-hydroxyphenylsulfonyl)py...)
Affinity DataIC50:  260nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176476((5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...)
Affinity DataIC50:  320nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150385(2-[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carb...)
Affinity DataIC50:  490nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071561(3-Hydroxy-4-{(2S,3S)-3-methyl-2-[2-(naphthalen-2-y...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187217(2,4-dichloro-6-{[(2S)-2-(2H-tetrazol-5-yl)pyrrolid...)
Affinity DataIC50:  560nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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