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Found 1774 with Last Name = 'overkleeft' and Initial = 'hs'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM162702(US9056847, Fluorophore 1-cyclophellitol)
Affinity DataKi:  0.950nM IC50:  2nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM60418(US9056847, Fluorophore 2-cyclophellitol)
Affinity DataKi:  1.56nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36514(CID46912122 | MDW933, 5)
Affinity DataKi:  7nM ΔG°:  -48.4kJ/mole IC50:  1.24nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36515(CID46912120 | MDW941, 6)
Affinity DataKi:  8nM ΔG°:  -48.1kJ/mole IC50:  1.94nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50398211(CHEMBL2181036)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50002834(CHEMBL3233658)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36513(CID46912128 | KY170, 4 | US9056847, Azido-cyclophe...)
Affinity DataKi:  44nM ΔG°:  -43.7kJ/mole IC50:  120nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50002835(CHEMBL3233659)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36513(CID46912128 | KY170, 4 | US9056847, Azido-cyclophe...)
Affinity DataKi:  83nM IC50:  150nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50002836(CHEMBL3233660)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376888(CHEMBL415279)
Affinity DataKi:  140nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM36512(CID164227 | Cylcophellitol, 3 | US11826435, Compou...)
Affinity DataKi:  152nM ΔG°:  -40.5kJ/mole IC50:  150nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376892(CHEMBL406958)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50002833(CHEMBL3233657)
Affinity DataKi:  244nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376889(CHEMBL260647)
Affinity DataKi:  260nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376893(CHEMBL262334)
Affinity DataKi:  380nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376878(CHEMBL436906)
Affinity DataKi:  400nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376877(CHEMBL259878)
Affinity DataKi:  480nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376883(CHEMBL404611)
Affinity DataKi:  500nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376873(CHEMBL438168)
Affinity DataKi:  510nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376896(CHEMBL262599)
Affinity DataKi:  530nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376890(CHEMBL261649)
Affinity DataKi:  580nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376895(CHEMBL406960)
Affinity DataKi:  600nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376875(CHEMBL260812)
Affinity DataKi:  620nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol lipase-alpha(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048620(CHEMBL3319620)
Affinity DataKi:  700nMAssay Description:Inhibition of human DAGLalpha expressed in HEK293T cell membranes assessed as reduction in hydrolysis of inhibition of [14C]-sn-1-oleoyl-2-arachidono...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376899(CHEMBL260318)
Affinity DataKi:  700nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376876(CHEMBL408760)
Affinity DataKi:  720nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376874(CHEMBL260750)
Affinity DataKi:  740nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376891(CHEMBL439076)
Affinity DataKi:  770nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048620(CHEMBL3319620)
Affinity DataKi:  800nMAssay Description:Inhibition of human ABHD6 expressed in HEK293T cell membranes assessed as reduction in glycerol production using 2-arachidonoyl glycerol substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376880(CHEMBL436862)
Affinity DataKi:  820nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376885(CHEMBL262335)
Affinity DataKi:  840nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376884(CHEMBL429690)
Affinity DataKi:  850nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376897(CHEMBL406084)
Affinity DataKi:  930nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376879(CHEMBL266172)
Affinity DataKi:  930nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376900(CHEMBL258970)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376898(CHEMBL408759)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376894(CHEMBL259220)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376881(CHEMBL406713)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048618(CHEMBL3319622)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of human ABHD6 expressed in HEK293T cell membranes assessed as reduction in glycerol production using 2-arachidonoyl glycerol substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376887(CHEMBL436878)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376886(CHEMBL436697)
Affinity DataKi:  3.30E+3nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50376882(CHEMBL437260)
Affinity DataKi:  5.30E+3nMAssay Description:Displacement of [125I]triptorelin from human GnRHR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  7.73E+3nM IC50:  1.20E+4nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50048621(CHEMBL3319619)
Affinity DataKi:  1.83E+4nMAssay Description:Inhibition of human ABHD6 expressed in HEK293T cell membranes assessed as reduction in glycerol production using 2-arachidonoyl glycerol substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Academisch Medisch Centrum Bij Universiteit Van Amsterdam

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)
Affinity DataKi:  5.30E+4nM ΔG°:  -25.4kJ/mole IC50:  9.49E+3nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028179(CHEMBL3354624)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028244(CHEMBL3354627)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028180(CHEMBL3354625)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50028254(CHEMBL3354634)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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