Compile Data Set for Download or QSAR
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Found 120 with Last Name = 'owen' and Initial = 'sn'
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117522((5S,6R,9S)-5-(4-Fluoro-phenyl)-9-(2-trifluoromethy...)
Affinity DataKi:  28nMAssay Description:Binding affinity of the compound to human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117508((5S,6R,9R)-5-(4-Fluoro-phenyl)-9-(2-trifluoromethy...)
Affinity DataKi:  400nMAssay Description:Binding affinity of the compound to human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50403954(CHEMBL2112366)
Affinity DataIC50:  0.0800nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002660(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.0850nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118664(5-{3-[2-Methoxy-5-(5-trifluoromethyl-tetrazol-1-yl...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117523(5-{(5S,10S)-5-(4-Fluoro-phenyl)-10-[2-methoxy-5-(5...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117509((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-[2-methoxy-5-(5...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118667(7-(1H-Imidazol-4-ylmethyl)-3-[2-methoxy-5-(5-trifl...)
Affinity DataIC50:  0.110nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118666(3-[2-Methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-p...)
Affinity DataIC50:  0.110nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029884((2S,3S)-2-Benzhydryl-3-(3,5-bis-trifluoromethyl-be...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029878((2R,3S)-2-Benzhydryl-3-(3,5-bis-trifluoromethyl-be...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50403953(CHEMBL2112368)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029847(2-Benzhydryl-3-(3-iodo-5-methyl-benzyloxy)-1-aza-b...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118671(3-(2-Methoxy-5-trifluoromethoxy-phenyl)-6-phenyl-1...)
Affinity DataIC50:  0.350nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117515(5-[(3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(2-methoxy-p...)
Affinity DataIC50:  0.560nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118670(3-(2-Methoxy-5-trifluoromethoxy-phenyl)-6-phenyl-7...)
Affinity DataIC50:  0.890nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029871(2-Benzhydryl-3-(3,5-dimethyl-benzyloxy)-1-aza-bicy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029871(2-Benzhydryl-3-(3,5-dimethyl-benzyloxy)-1-aza-bicy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029869(2-Benzhydryl-3-(3-methyl-5-trimethylsilanyl-benzyl...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281976((2S,3S)-2-Benzhydryl-3-(3,5-dimethyl-benzyloxy)-1-...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117510(CHEMBL84881 | {5-[5-(4-Fluoro-phenyl)-9-(2-trifluo...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117516((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(2-methoxy-5-tr...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117521(CHEMBL85626 | {5-[5-(4-Fluoro-phenyl)-9-(2-trifluo...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029879(2-Benzhydryl-3-(3-methoxy-5-methyl-benzyloxy)-1-az...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029879(2-Benzhydryl-3-(3-methoxy-5-methyl-benzyloxy)-1-az...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029839(2-Benzhydryl-3-(3,5-bis-trifluoromethyl-benzyloxy)...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029839(2-Benzhydryl-3-(3,5-bis-trifluoromethyl-benzyloxy)...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029884((2S,3S)-2-Benzhydryl-3-(3,5-bis-trifluoromethyl-be...)
Affinity DataIC50:  2nMAssay Description:Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281976((2S,3S)-2-Benzhydryl-3-(3,5-dimethyl-benzyloxy)-1-...)
Affinity DataIC50:  2nMAssay Description:Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117514((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(5-isopropyl-2-...)
Affinity DataIC50:  2.80nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029850(3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-(1,2-diphe...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118662(3-(2-Methoxy-phenyl)-6-phenyl-1-oxa-7-aza-spiro[4....)
Affinity DataIC50:  6.5nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029876(3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-(cyclohexy...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029875(2-Benzhydryl-3-(3,5-dimethoxy-benzyloxy)-1-aza-bic...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029875(2-Benzhydryl-3-(3,5-dimethoxy-benzyloxy)-1-aza-bic...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029845(2-Benzhydryl-3-(3,5-dichloro-benzyloxy)-1-aza-bicy...)
Affinity DataIC50:  9nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029845(2-Benzhydryl-3-(3,5-dichloro-benzyloxy)-1-aza-bicy...)
Affinity DataIC50:  9nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117511((3S,5S,10S)-10-(5-Fluoro-2-methoxy-phenyl)-5-(4-fl...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117518((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(2-methoxy-phen...)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117524((3S,5S,10S)-10-(2,5-Dimethoxy-phenyl)-5-(4-fluoro-...)
Affinity DataIC50:  16nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117506(5-(5,9-Diphenyl-1,7-dioxa-4-aza-spiro[5.5]undec-4-...)
Affinity DataIC50:  19nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029872(2-Benzhydryl-3-(3-methyl-benzyloxy)-1-aza-bicyclo[...)
Affinity DataIC50:  20nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281980((2S,3S)-2-Benzhydryl-3-(3-methyl-benzyloxy)-1-aza-...)
Affinity DataIC50:  21nMAssay Description:Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117507((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(2-trifluoromet...)
Affinity DataIC50:  24nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117513((3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(3-trifluoromet...)
Affinity DataIC50:  30nMAssay Description:Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029842(2-Benzhydryl-3-(3,5-difluoro-benzyloxy)-1-aza-bicy...)
Affinity DataIC50:  33nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029863(2-Benzhydryl-3-(2,5-dimethyl-benzyloxy)-1-aza-bicy...)
Affinity DataIC50:  36nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029857(2-Benzhydryl-3-(3-fluoro-benzyloxy)-1-aza-bicyclo[...)
Affinity DataIC50:  37nMAssay Description:Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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