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Found 169 with Last Name = 'pais' and Initial = 'gc'
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50103243(4-{2-[2-(2-Acetylamino-3-carboxy-propionylamino)-p...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50103235(5-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50103240(4-Carbamoyl-4-{[6-(difluoro-phosphono-methyl)-naph...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50103227(6-(Difluoro-phosphono-methyl)-naphthalene-2-carbox...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50103238(3-Carboxymethoxy-naphthalene-2,7-dicarboxylic acid...)
Affinity DataKi:  2.50E+5nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50103234(2-Carboxymethoxy-naphthalene-1,6-dicarboxylic acid...)
Affinity DataKi:  9.00E+5nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50103231(CHEMBL98615 | Naphthalene-2,7-dicarboxylic acid)
Affinity DataKi: >3.20E+6nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50103242(CHEMBL316894 | Naphthalene trisulfonate (NTS) | na...)
Affinity DataKi: >4.00E+6nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125697(4-(3,4-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125697(4-(3,4-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Affinity DataIC50:  260nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (3'processing)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125701(4-(5,8-Diazido-5,6,7,8-tetrahydro-naphthalen-2-yl)...)
Affinity DataIC50:  320nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  350nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  350nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125699(4-(1,3-Diazido-indan-5-yl)-2,4-dioxo-butyric acid ...)
Affinity DataIC50:  360nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM107681((2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxo...)
Affinity DataIC50:  480nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM107681((2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxo...)
Affinity DataIC50:  480nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM107693((2Z)-4-(5-chloro-1H-indol-3-yl)-2-hydroxy-4-oxobut...)
Affinity DataIC50:  520nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50093435((Z)-1-(5-Chloro-1H-indol-3-yl)-3-hydroxy-3-(1H-tet...)
Affinity DataIC50:  650nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330327((R)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cy...)
Affinity DataIC50:  680nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483850(CHEMBL1774147)
Affinity DataIC50:  680nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056891(2-Hydroxy-benzoic acid N'-(2-hydroxy-benzoyl)-hydr...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in strand transfer of preassembleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50370120(CHEMBL611459)
Affinity DataIC50:  810nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483849(CHEMBL1774153)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115582((Z)-4-[4-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Affinity DataIC50:  1.28E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483851(CHEMBL1774264)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115570((Z)-2-Hydroxy-4-(1H-indol-3-yl)-4-oxo-but-2-enoic ...)
Affinity DataIC50:  1.43E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125705(4-[3-(2-Cyano-ethyl)-phenyl]-2,4-dioxo-butyric aci...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration of the compound was determined against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125704(4-(3-Azidomethyl-phenyl)-2,4-dioxo-butyric acid | ...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50476068(CHEMBL219534)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115575(1-(5-Fluoro-1H-indol-3-yl)-3-hydroxy-3-(1H-tetrazo...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125705(4-[3-(2-Cyano-ethyl)-phenyl]-2,4-dioxo-butyric aci...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115580((Z)-4-[3-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115573(3-Hydroxy-1-(1H-indol-3-yl)-3-(1H-tetrazol-5-yl)-p...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056891(2-Hydroxy-benzoic acid N'-(2-hydroxy-benzoyl)-hydr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in 3''-processing of preassembleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125702(4-(3,5-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50083953((Z)-4-(3-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115573(3-Hydroxy-1-(1H-indol-3-yl)-3-(1H-tetrazol-5-yl)-p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50476067(CHEMBL219216)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50476066(CHEMBL436512)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50121970(11,12,13,14,25,26,27,28-octahydrotetrabenzo[c,i,m,...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in 3''-processing of preassembleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125702(4-(3,5-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50083953((Z)-4-(3-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50121972(CHEMBL157373 | Compound 3)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in 3''-processing of preassembleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483850(CHEMBL1774147)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50476065(CHEMBL220656)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50121972(CHEMBL157373 | Compound 3)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in strand transfer of preassembleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330327((R)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cy...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50121971(2-Mercapto-benzoic acid N'-(2-mercapto-benzoyl)-hy...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and drug for 30 min followed by DNA for 1h) in strand transfer of preassembleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50121970(11,12,13,14,25,26,27,28-octahydrotetrabenzo[c,i,m,...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and DNA on ice for 15 min followed by drug for 1h) in strand transfer of postass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50121970(11,12,13,14,25,26,27,28-octahydrotetrabenzo[c,i,m,...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against HIV-1 integrase (preincubated with Mn+2, and DNA on ice for 15 min followed by drug for 1h) in 3'' processing of postasse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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