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Found 1214 with Last Name = 'parsons' and Initial = 'wh'
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325767(3-(2'-chlorobiphenyl-3-yl)-1H-pyrazole-1-carboxami...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325766(3-(2'-chlorobiphenyl-4-yl)-1H-pyrazole-1-carboxami...)
Affinity DataKi:  0.111nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50280339((S)-2-[4-(2-Benzenesulfonyl-ethoxy)-3-methoxy-5-(p...)
Affinity DataKi:  1nMAssay Description:Compound was evaluated for inhibition of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002827(1-{3-(3-Hydroxy-propoxy)-2-propoxy-5-[(2S,5S)-5-(3...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002828(1-{3-(3-Morpholin-4-yl-propoxy)-2-propoxy-5-[(2S,5...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002824((S)-5-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-tri...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002827(1-{3-(3-Hydroxy-propoxy)-2-propoxy-5-[(2S,5S)-5-(3...)
Affinity DataKi:  2.90nMAssay Description:In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002826(1-{3-(3-Imidazol-1-yl-propoxy)-2-propoxy-5-[(2S,5S...)
Affinity DataKi:  3nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)
Affinity DataKi:  3.20nMAssay Description:In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002824((S)-5-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-tri...)
Affinity DataKi:  3.70nMAssay Description:In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002825((R)-5-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-tri...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002825((R)-5-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-tri...)
Affinity DataKi:  3.72nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)
Affinity DataKi:  6nMAssay Description:In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086717(JNJ-39439335 | Mavatrep)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-RTX from human TRPV1 transfected in HEK293 cells after 60 mins by scintillation spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM81972((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Affinity DataKi:  9nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325765(3-(4-(4-chloro-2-fluorophenoxy)phenyl)-1H-pyrazole...)
Affinity DataKi:  13nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM81972((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Affinity DataKi:  14.3nMAssay Description:In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataKi:  15nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325819((Z)-5-((2'-(trifluoromethoxy)biphenyl-3-yl)methyle...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human Nav1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187039(1-(3,4-dichlorobenzyl)-5-hydroxy-1H-indole-2-carbo...)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164039((1S,2S)-Cyclopentane-1,2-dicarboxylic acid 1-[(bip...)
Affinity DataKi:  30nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataKi:  40nMAssay Description:Binding affinity at human inactive state Nav1.7 by whole cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091438((E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-...)
Affinity DataKi:  50nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164048((1S,2S)-Cyclopentane-1,2-dicarboxylic acid 1-[([2,...)
Affinity DataKi:  50nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164043((1S,2S)-Cyclopentane-1,2-dicarboxylic acid 1-[([2,...)
Affinity DataKi:  60nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366241(CHEMBL297624 | L-652731)
Affinity DataKi:  103nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164070((1S,2S)-2-[(2''-Trifluoromethyl-biphenyl-4-ylmethy...)
Affinity DataKi:  110nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002822((-)-trans 42s,5S)-2-[3-[(2-Oxopropyl)sulfony1]-4-n...)
Affinity DataKi:  110nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164042((1S,2S)-2-[(2''-Methyl-biphenyl-4-ylmethyl)-amino]...)
Affinity DataKi:  130nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164067((1S,2S)-2-[(2''-Methanesulfonyl-biphenyl-4-ylmethy...)
Affinity DataKi:  140nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164058(CHEMBL360307 | N-[2,2'']Bithiophenyl-5-ylmethyl-N'...)
Affinity DataKi:  140nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50166790(CHEMBL364912 | {2-[2-(4-Chloro-phenyl)-thiazol-4-y...)
Affinity DataKi:  140nMAssay Description:In vitro inhibitory concentration against Na v1.7 channel electrophysiology in inactivated state expressed in HEK293 cells using Voltage/Ion Probe Re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164047(CHEMBL361097 | N-[2,2'']Bithiophenyl-5-ylmethyl-N'...)
Affinity DataKi:  150nMAssay Description:Inhibition of peripheral nerve sodium channel NaV1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164047(CHEMBL361097 | N-[2,2'']Bithiophenyl-5-ylmethyl-N'...)
Affinity DataKi:  150nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164051((1S,2S)-2-[(2''-Methoxy-biphenyl-4-ylmethyl)-amino...)
Affinity DataKi:  160nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50166787(CHEMBL195235 | {2-[2-(4-Chloro-phenyl)-thiazol-4-y...)
Affinity DataKi:  160nMAssay Description:In vitro inhibitory concentration against Na v1.7 channel electrophysiology in inactivated state expressed in HEK293 cells using Voltage/Ion Probe Re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002822((-)-trans 42s,5S)-2-[3-[(2-Oxopropyl)sulfony1]-4-n...)
Affinity DataKi:  174nMAssay Description:In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164040((1S,2S)-Cyclopentane-1,2-dicarboxylic acid 1-[meth...)
Affinity DataKi:  210nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataKi:  230nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178865(CHEMBL203440 | trans-N-benzyl-2-(1-hydroxy-3-(3-(t...)
Affinity DataKi:  230nMAssay Description:Inhibition of peripheral nerve sodium channel NaV1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164062((1S,2S)-Cyclopentane-1,2-dicarboxylic acid 1-[meth...)
Affinity DataKi:  280nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178861((1R,2R)-N1-methyl-N1-((2'-sulfamoylbiphenyl-4-yl)m...)
Affinity DataKi:  290nMAssay Description:Inhibition of peripheral nerve sodium channel NaV1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178859(CHEMBL205258 | trans-N-benzyl-2-(1-hydroxy-3-(2-(t...)
Affinity DataKi:  320nMAssay Description:Inhibition of peripheral nerve sodium channel NaV1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164057((1S,2S)-2-[Methyl-(2''-trifluoromethyl-biphenyl-4-...)
Affinity DataKi:  330nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178867(CHEMBL206431 | N-((trans-2-(1-hydroxy-3-phenylprop...)
Affinity DataKi:  330nMAssay Description:Inhibition of peripheral nerve sodium channel NaV1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataKi:  340nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141073((E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecar...)
Affinity DataKi:  360nMAssay Description:Binding affinity to human Nav1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178863(CHEMBL203185 | trans-N-benzyl-2-((S)-1-hydroxy-3-(...)
Affinity DataKi:  360nMAssay Description:Inhibition of peripheral nerve sodium channel NaV1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164068((1S,2S)-Cyclopentane-1,2-dicarboxylic acid 1-[(2''...)
Affinity DataKi:  360nMAssay Description:Inhibitory constant against voltage-gated sodium channel Nav1.7 in electrophysiology assays (EP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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