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Found 115 with Last Name = 'pawlitz' and Initial = 'jl'
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332752((2R)-6,8-dichloro-7-(2-methylpropoxy)-2-(trifluoro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331873(5,6-dichloro-2-(trifluoromethyl)-2H-chromene-3-car...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332761(7-tert-butyl-6-chloro-2-(trifluoromethyl)-2H-chrom...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332769((R)-6-chloro-7-propyl-2-(trifluoromethyl)-2H-chrom...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331879(5,6,7-trichloro-2-(trifluoromethyl)-2H-chromene-3-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026234(CHEMBL1630239)
Affinity DataIC50: <6nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332771((R)-6-chloro-7-isobutyl-2-(trifluoromethyl)-2H-chr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332773((R)-6-chloro-7-(isobutylthio)-2-(trifluoromethyl)-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331887((2S)-6,8-dichloro-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331887((2S)-6,8-dichloro-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331873(5,6-dichloro-2-(trifluoromethyl)-2H-chromene-3-car...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19440(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19439(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331875(6,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-car...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331881(6-chloro-2-(trifluoromethyl)-8-vinyl-2H-chromene-3...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332765(6-chloro-7-(isobutylthio)-2-(trifluoromethyl)-2H-c...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332763(6-chloro-7-isobutyl-2-(trifluoromethyl)-2H-chromen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026213(CHEMBL1630240)
Affinity DataIC50: <21nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332752((2R)-6,8-dichloro-7-(2-methylpropoxy)-2-(trifluoro...)
Affinity DataIC50: <28nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026214(CHEMBL1630241)
Affinity DataIC50: <28nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332753(6,8-dichloro-7-(cyclohexylmethoxy)-2-(trifluoromet...)
Affinity DataIC50: <34nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19435(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  40nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331882(6-chloro-8-ethynyl-2-(trifluoromethyl)-2H-chromene...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331880(6,7,8-trichloro-2-(trifluoromethyl)-2H-chromene-3-...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332759(6-chloro-7-(2-ethylbutoxy)-2-(trifluoromethyl)-2H-...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19430(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332768((2S)-7-tert-butyl-6-chloro-2-(trifluoromethyl)-2H-...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331874(6,7-dichloro-2-(trifluoromethyl)-2H-chromene-3-car...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19438(4-{5-[(8aS)-octahydropyrrolo[1,2-a]piperazin-2-yl]...)
Affinity DataIC50:  62nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332777((R)-6-chloro-7-isopentyl-2-(trifluoromethyl)-2H-ch...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332766(6-chloro-7-(isobutyl(methyl)amino)-2-(trifluoromet...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332775((R)-6-chloro-7-(isobutyl(methyl)amino)-2-(trifluor...)
Affinity DataIC50:  85nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332764(6-chloro-7-isopentyl-2-(trifluoromethyl)-2H-chrome...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331877(5,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-car...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19437(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331883(6-chloro-8-phenyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332744(6-chloro-5-methyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19431(4-[3-(4-chlorophenyl)-5-(3,5-dimethylpiperidin-1-y...)
Affinity DataIC50:  130nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19432(4-[3-(4-chlorophenyl)-5-(4-methylpiperidin-1-yl)-1...)
Affinity DataIC50:  130nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332770((S)-6-chloro-7-propyl-2-(trifluoromethyl)-2H-chrom...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026234(CHEMBL1630239)
Affinity DataIC50: <140nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026213(CHEMBL1630240)
Affinity DataIC50: <140nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026214(CHEMBL1630241)
Affinity DataIC50: <140nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331881(6-chloro-2-(trifluoromethyl)-8-vinyl-2H-chromene-3...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50331884(6-chloro-8-(phenylethynyl)-2-(trifluoromethyl)-2H-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332762(6-chloro-7-propyl-2-(trifluoromethyl)-2H-chromene-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332774((S)-6-chloro-7-(isobutylthio)-2-(trifluoromethyl)-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19434(2-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19436(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19433(2-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  260nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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