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Found 278 with Last Name = 'pechulis' and Initial = 'ad'
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50290071(CHEMBL542149 | N-[(S)-1-(3-Amino-phenyl)-2-pyrroli...)
Affinity DataKi:  0.0592nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor kappa1 binding to guinea pig brain membranes, using 1 nM [3H]- U69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50290076(CHEMBL558596 | N-[(S)-1-(3-Acetylamino-phenyl)-2-p...)
Affinity DataKi:  0.0855nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor kappa1 binding to guinea pig brain membranes, using 1 nM [3H]- U69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290072(5-{3-[3-((S)-1-{[2-(3,4-Dichloro-phenyl)-acetyl]-m...)
Affinity DataKi:  0.898nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor delta 1 binding to guinea pig brain membranes, using 0.2 nM [3H]-naltrindole as radiolig...More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50290072(5-{3-[3-((S)-1-{[2-(3,4-Dichloro-phenyl)-acetyl]-m...)
Affinity DataKi:  1.40nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor kappa1 binding to guinea pig brain membranes, using 1 nM [3H]- U69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290070(5-{3-[3-(1-{[2-(3,4-Dichloro-phenyl)-acetyl]-methy...)
Affinity DataKi:  1.80nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor delta 1 binding to guinea pig brain membranes, using 0.2 nM [3H]-naltrindole as radiolig...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTransporter(Rattus norvegicus (rat))
Amri

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401743(CHEMBL2206526)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401732(CHEMBL2206507)
Affinity DataKi:  5nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401731(CHEMBL2206508)
Affinity DataKi:  5.80nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  5.97nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTransporter(Rattus norvegicus (rat))
Amri

Curated by ChEMBL
LigandPNGBDBM50401730(CHEMBL2206509)
Affinity DataKi:  6.30nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401730(CHEMBL2206509)
Affinity DataKi:  7.10nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401744(CHEMBL2206525)
Affinity DataKi:  7.20nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401737(CHEMBL2206532)
Affinity DataKi:  7.30nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50054539(CHEMBL3323088)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290071(CHEMBL542149 | N-[(S)-1-(3-Amino-phenyl)-2-pyrroli...)
Affinity DataKi:  7.70nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor mu 1 binding to guinea pig brain membranes, using [3H]- DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290071(CHEMBL542149 | N-[(S)-1-(3-Amino-phenyl)-2-pyrroli...)
Affinity DataKi:  7.80nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor delta 1 binding to guinea pig brain membranes, using 0.2 nM [3H]-naltrindole as radiolig...More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50290070(5-{3-[3-(1-{[2-(3,4-Dichloro-phenyl)-acetyl]-methy...)
Affinity DataKi:  8.20nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor kappa1 binding to guinea pig brain membranes, using 1 nM [3H]- U69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50290076(CHEMBL558596 | N-[(S)-1-(3-Acetylamino-phenyl)-2-p...)
Affinity DataKi:  8.40nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor mu 1 binding to guinea pig brain membranes, using [3H]- DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401738(CHEMBL2206531)
Affinity DataKi:  9nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401740(CHEMBL2206529)
Affinity DataKi:  10.6nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401716(CHEMBL2206524)
Affinity DataKi:  12.3nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401735(CHEMBL2206534)
Affinity DataKi:  13nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401742(CHEMBL2206527)
Affinity DataKi:  13.5nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401733(CHEMBL2206536)
Affinity DataKi:  14nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290076(CHEMBL558596 | N-[(S)-1-(3-Acetylamino-phenyl)-2-p...)
Affinity DataKi:  14nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor delta 1 binding to guinea pig brain membranes, using 0.2 nM [3H]-naltrindole as radiolig...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401734(CHEMBL2206535)
Affinity DataKi:  15nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50290074(CHEMBL558597 | N-[(R)-1-(3-Amino-phenyl)-2-pyrroli...)
Affinity DataKi:  15nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor kappa1 binding to guinea pig brain membranes, using 1 nM [3H]- U69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401736(CHEMBL2206533)
Affinity DataKi:  16.5nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50290075(CHEMBL542403 | N-[(R)-1-(3-Acetylamino-phenyl)-2-p...)
Affinity DataKi:  18nMAssay Description:Compound was evaluated for the inhibition of Opioid receptor kappa1 binding to guinea pig brain membranes, using 1 nM [3H]- U69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401740(CHEMBL2206529)
Affinity DataKi:  19nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
Amri

Curated by ChEMBL
LigandPNGBDBM50005548((+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataKi:  20nMAssay Description:Inhibition of rat NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401736(CHEMBL2206533)
Affinity DataKi:  21.5nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50005548((+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataKi:  23nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401717(CHEMBL2206523)
Affinity DataKi:  25nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401737(CHEMBL2206532)
Affinity DataKi:  25nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401734(CHEMBL2206535)
Affinity DataKi:  27nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401717(CHEMBL2206523)
Affinity DataKi:  28nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401739(CHEMBL2206530)
Affinity DataKi:  29nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401743(CHEMBL2206526)
Affinity DataKi:  30.1nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401721(CHEMBL2206518)
Affinity DataKi:  31.8nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50062912(CHEMBL796 | Methylphenidate | alpha-phenyl-2-piper...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]WIN 35,428 from human DAT expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401723(CHEMBL2206516)
Affinity DataKi:  35nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401728(CHEMBL2206511)
Affinity DataKi:  35nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401732(CHEMBL2206507)
Affinity DataKi:  36nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50054539(CHEMBL3323088)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]WIN 35,428 from human DAT expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401730(CHEMBL2206509)
Affinity DataKi:  36.2nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401741(CHEMBL2206528)
Affinity DataKi:  37nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401717(CHEMBL2206523)
Affinity DataKi:  38nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50401729(CHEMBL2206510)
Affinity DataKi:  40.5nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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