TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Ulm University Hospital
Curated by ChEMBL
Ulm University Hospital
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant CK1delta kinase domain by Cherenkov countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant VEGFR3More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant CK1delta kinase domain by Cherenkov countingMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 9.60nMAssay Description:Inhibition of human recombinant BRAF V600E mutant using MEK1 as substrate measured after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATPMore data for this Ligand-Target Pair
TargetPyruvate kinase(Staphylococcus aureus (strain MRSA252))
Christian-Albrechts-University Of Kiel
Curated by ChEMBL
Christian-Albrechts-University Of Kiel
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of methicillin-resistant Staphylococcus aureus pyruvate kinase by coupled lactate dehydrogenase continuous assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Christian-Albrechts-University Of Kiel
Curated by ChEMBL
Christian-Albrechts-University Of Kiel
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrateMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant BRAF V600E mutant using MEK1 as substrate measured after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human CK1delta transcription variant 1 using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by C...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of p38alpha MAPK by non-radioactive immunosorbent assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant CK1delta kinase domain by Cherenkov countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human recombinant VEGFR3More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of rat recombinant GST-tagged CK1delta using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by Cher...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of human CK1delta transcription variant 2 using GST-tagged mouse p53 (1 to 64 residues) as substrate in presence of radiolabelled-ATP by C...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of recombinant CK1epsilon by Cherenkov counting in presence of 20 uM ATPMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of rat recombinant CK1delta kinase domain using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counti...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Christian-Albrechts-University Of Kiel
Curated by ChEMBL
Christian-Albrechts-University Of Kiel
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrateMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant CK1delta kinase domain by Cherenkov countingMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Technical University Dortmund
Curated by ChEMBL
Technical University Dortmund
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of CK1delta by Cherenkov counting in presence of 20 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Technical University Dortmund
Curated by ChEMBL
Technical University Dortmund
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ...More data for this Ligand-Target Pair
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Ulm University Hospital
Curated by ChEMBL
Ulm University Hospital
Curated by ChEMBL
Affinity DataIC50: 157nMAssay Description:Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University Medical Center Groningen
Curated by ChEMBL
University Medical Center Groningen
Curated by ChEMBL
Affinity DataIC50: 157nMAssay Description:Inhibition of human recombinant N-terminal GST/His6-tagged BRAF V600E mutant (Q417 to H766 residues) expressed in Sf9 insect cells using MEK1 as subs...More data for this Ligand-Target Pair