Found 275 with Last Name = 'phuan' and Initial = 'pw' TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human CFTR chloride conductance expressed in forskolin-stimulated rat FRT cells by short-circuit current analysis in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 11nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of UT-B in human erythrocytes assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of UT-B-mediated urea transport in wild type CD1 mouse erythrocytes incubated for 10 mins prior to urea addition by Stopped-flow light sca...More data for this Ligand-Target Pair
Affinity DataIC50: 25.1nMAssay Description:Reversible inhibition of mouse UT-B-mediated urea transportMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of [3H]norepinephrine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of TMEM16A (unknown origin) expressed in Xenopus laevis oocytes at -60 mV holding potential by voltage-clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 104nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 153nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 196nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 212nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 353nMAssay Description:Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:In vitro inhibition of [3H]5-HT transporter uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of human TMEM16B expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:In vitro inhibition of [3H]dopamine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
Affinity DataIC50: 468nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 537nMAssay Description:Inhibition of UT-B in wild type CD1 mouse erythrocyte assessed as hemolysis after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 660nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
Affinity DataIC50: >800nMAssay Description:Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
Affinity DataIC50: >800nMAssay Description:Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
Affinity DataIC50: >800nMAssay Description:Inhibition of UT-B in mouse acetamide-loaded erythrocyte assessed as increase of hypotonic lysisMore data for this Ligand-Target Pair
