Affinity DataKi: 0.0776nMAssay Description:Antagonist activity at recombinant rat OX2R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.117nMAssay Description:Antagonist activity at recombinant rat OX1R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.126nMAssay Description:Antagonist activity at recombinant human OX1R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Antagonist activity at recombinant human OX1R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Antagonist activity at recombinant human OX2R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.316nMAssay Description:Antagonist activity at recombinant human OX1R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.398nMAssay Description:Antagonist activity at recombinant human OX2R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
Affinity DataKi: 0.759nMAssay Description:Displacement of [3H]almorexant from recombinant human OX1R expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
Affinity DataKi: 0.794nMAssay Description:Antagonist activity at recombinant human OX2R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Antagonist activity at recombinant human OX1R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataKi: 1.18nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
Affinity DataKi: 1.29nMAssay Description:Displacement of [3H]almorexant from recombinant human OX2R expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation cou...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation cou...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation cou...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor expressed in HEK293 membranes incubated for 120 mins by liquid scintillation countin...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H](+)pentazocine from human sigma 1 receptor transfected in HEK293 cell membranes after 120 mins by scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 2B receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor expressed in HEK293 membranes incubated for 120 mins by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-nisoxetine from human NET expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity against 5-hydroxytryptamine 2B receptorMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Displacement of [3H](+)-pentazocine from human sigma 1 receptor transfected in HEK293 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 5.01nMAssay Description:Antagonist activity at recombinant human OX2R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.01nMAssay Description:Antagonist activity at recombinant human OX1R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H](+)pentazocine from human sigma 1 receptor transfected in HEK293 cell membranes after 120 mins by scintillation counterMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 5.5nMAssay Description:Displacement of [3H](+)pentazocine from human sigma 1 receptor transfected in HEK293 cell membranes after 120 mins by scintillation counterMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University of Michigan
Curated by PDSP Ki Database
University of Michigan
Curated by PDSP Ki Database
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation cou...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor expressed in HEK293 membranes incubated for 120 mins by liquid scintillation countin...More data for this Ligand-Target Pair