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TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataKi:  10nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322158(2-(3-(4-((1H-indazol-5-yl)amino)-6-(4-methylpipera...)
Affinity DataKi:  20nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322152((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Affinity DataKi:  20nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322153(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Affinity DataKi:  30nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)
Affinity DataKi:  40nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)
Affinity DataKi:  40nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM448554(US10696660, Y-27263 | US11311541, Example Y-27263)
Affinity DataKi:  60nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322152((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Affinity DataKi:  70nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Affinity DataKi:  80nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322157(2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)phe...)
Affinity DataKi:  170nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322159((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Affinity DataKi:  180nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322154(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Affinity DataKi:  260nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322155(US10183931, SLx-2119 | US10696660, SLx-2119 | US11...)
Affinity DataKi:  500nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322159((R)-2-(3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl...)
Affinity DataKi:  870nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM322153(2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...)
Affinity DataKi:  2.01E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598601(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: <0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598664(Ethyl 2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluo...)
Affinity DataIC50:  0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598596(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...)
Affinity DataIC50: <0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50:  0.200nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598630(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...)
Affinity DataIC50:  0.400nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598602(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50:  0.400nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50:  0.900nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598603(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50:  1nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598647(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluoro-...)
Affinity DataIC50:  1.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578446((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(4-chloropheny...)
Affinity DataIC50:  1.20nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598655(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N4-ethyl-N6-...)
Affinity DataIC50:  1.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598604(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50:  1.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578479((S)—N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-...)
Affinity DataIC50:  1.60nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598562(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)pyrimidin...)
Affinity DataIC50:  1.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50:  1.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578424(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-chlorophenyl)-2...)
Affinity DataIC50:  1.70nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598666(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chloro-N4-...)
Affinity DataIC50:  1.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598652(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N4-(1H-indaz...)
Affinity DataIC50:  1.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578438((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50:  1.80nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578449(3-(2-((4-(1H-pyrazol-4-yl)phenyl)amino)-1-(methyla...)
Affinity DataIC50:  1.90nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598631(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluoro-...)
Affinity DataIC50:  2.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598606(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3,8-diazabicyclo[...)
Affinity DataIC50:  2.30nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578470(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50:  2.40nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598636(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...)
Affinity DataIC50:  2.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50:  2.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578435((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...)
Affinity DataIC50:  2.90nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578438((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50:  3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578410((S)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50:  3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578409(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(2-methoxyphenyl)-...)
Affinity DataIC50:  3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578454(N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-pyra...)
Affinity DataIC50:  3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598517(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)pyrimidin-...)
Affinity DataIC50:  3nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598577(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...)
Affinity DataIC50:  3.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578415(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(ethylamino)-2-(p-...)
Affinity DataIC50:  3.10nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578420(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-chlorophenyl)-2...)
Affinity DataIC50:  3.5nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598659(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N4-(1H-indaz...)
Affinity DataIC50:  3.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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