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Found 33 with Last Name = 'profeta' and Initial = 's'
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034013((S)-9-Bromo-4-ethyl-4-hydroxy-11-methyl-1,12-dihyd...)
Affinity DataIC50:  28nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034009((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  33nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034018((S)-4,11-Diethyl-4,N-dihydroxy-3,13-dioxo-3,4,12,1...)
Affinity DataIC50:  71nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034019((S)-9-Bromo-4,11-diethyl-4-hydroxy-1,12-dihydro-4H...)
Affinity DataIC50:  122nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034014((S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-3,4,12,...)
Affinity DataIC50:  143nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034015((S)-9-Aminomethyl-4,11-diethyl-4-hydroxy-1,12-dihy...)
Affinity DataIC50:  167nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034020((S)-9-Aminomethyl-4-ethyl-4-hydroxy-11-methyl-8-ox...)
Affinity DataIC50:  190nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034024(((S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-8-oxy-...)
Affinity DataIC50:  217nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034010((S)-9-Aminomethyl-4-ethyl-4-hydroxy-11-methyl-1,12...)
Affinity DataIC50:  232nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034016((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  268nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034011((S)-4,11-Diethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6...)
Affinity DataIC50:  336nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034030((S)-4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,8,12...)
Affinity DataIC50:  383nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034012((S)-9-(3-Amino-prop-1-ynyl)-4-ethyl-4-hydroxy-11-m...)
Affinity DataIC50:  505nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  700nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034025((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  949nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034017((S)-9-(3-Amino-prop-1-ynyl)-4,11-diethyl-4-hydroxy...)
Affinity DataIC50:  1.08E+3nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.08E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034029((S)-4-Ethyl-4-hydroxy-11-methyl-9-(3-morpholin-4-y...)
Affinity DataIC50:  1.11E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034021((S)-4-Ethyl-4-hydroxy-8-oxy-1,12-dihydro-4H-2-oxa-...)
Affinity DataIC50:  1.18E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034027((S)-9-(3-Dimethylamino-prop-1-ynyl)-4,11-diethyl-4...)
Affinity DataIC50:  1.33E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034022((S)-4,11-Diethyl-4-hydroxy-8-methyl-3,13-dioxo-3,4...)
Affinity DataIC50:  1.46E+3nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034028((S)-9-(3-Dimethylamino-propyl)-4,11-diethyl-4-hydr...)
Affinity DataIC50:  1.49E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50486978(CHEMBL49183)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM15011(2,4-diethyl 5-formyl-3-methyl-1H-pyrrole-2,4-dicar...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM15012(2,4-diethyl 3-ethyl-5-formyl-1H-pyrrole-2,4-dicarb...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50486983(CHEMBL48293)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50486985(CHEMBL48733)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50486979(CHEMBL296835)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50486984(CHEMBL299092)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50034023((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  9.33E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50486980(CHEMBL410501)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50486981(CHEMBL298963)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine biosynthesis bifunctional protein HisB(Escherichia coli (strain K12))
Monsanto

Curated by ChEMBL
LigandPNGBDBM50486982(CHEMBL296253)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed