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Found 298 with Last Name = 'rainoldi' and Initial = 's'
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279340((Z)-2-[(Furan-2-ylmethyl)-amino]-5-[1-(1H-pyrrolo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279338((Z)-2-(Benzylamino)-5-(1H-pyrrolo[2,3-b]pyridin-3-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279339((Z)-2-Isopropylamino-5-[1-(1H-pyrrolo[2,3-b]pyridi...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM27344(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Affinity DataIC50:  10nMAssay Description:Inhibition of cdc7More data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279251((Z)-2-[(4-Methylcyclohexyl)amino]-5-(1H-pyrrolo[2,...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279285((Z)-2-(Isopropylamino)-5-(1H-pyrrolo[2,3-b]pyridin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279215((Z)-2-[(2-Furylmethyl)amino]-5-(1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279338((Z)-2-(Benzylamino)-5-(1H-pyrrolo[2,3-b]pyridin-3-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Cdk9/cyclinT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279248((Z)-2-[(2-Phenylethyl)amino]-5-(1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279247((Z)-5-[1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)-methylide...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  20nMAssay Description:Inhibition of cdk9More data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279099((Z)-2-(Benzylamino)-5-(1H-pyrrolo[2,3-b]pyridin-3-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279214((Z)-2-((S)-1-Phenyl-ethylamino)-5-[1-(1H-pyrrolo[2...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279249((Z)-2-(Cyclohexylamino)-5-(1H-pyrrolo[2,3-b]pyridi...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279281((Z)-5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-[...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279335(CHEMBL484988 | Z)-2-[(3,3-Dimethylbutyl)amino]-5-(...)
Affinity DataIC50:  24nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279144((Z)-2-Piperidin-1-yl-5-(1H-pyrrolo[2,3-b]pyridin-3...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279372((Z)-2-((S)-1-Phenyl-ethylamino)-5-[1-(1H-pyrrolo[2...)
Affinity DataIC50:  26nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM124951(US8765972, 4)
Affinity DataIC50:  27nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction in H2O2-induced PAR formation incubated for 30 mins followed by H2O2 addition for 15 mi...More data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279143((Z)-2-(3-Methylphenyl)-5-(1H-pyrrolo[2,3-b]pyridin...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Nerviano Medical Sciences Oncology

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  30nMAssay Description:Inhibition of cdk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279250((Z)-2-(Cyclopropylamino)-5-(1H-pyrrolo[2,3-b]pyrid...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM27344(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Affinity DataIC50:  34nMAssay Description:Inhibition of cdk9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279286((Z)-2-(Pentylamino)-5-(1H-pyrrolo[2,3-b]pyridin-3-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279336((Z)-2-[(2-Hydroxyethyl)amino]-5-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279184((Z)-2-[(3-Chlorobenzyl)amino]-5-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50:  39nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataIC50:  40nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138344(US8877944, 49)
Affinity DataIC50:  40nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences Oncology

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  40nMAssay Description:Inhibition of cdk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279284((Z)-2-(Ethylamino)-5-(1H-pyrrolo[2,3-b]pyridin-3-y...)
Affinity DataIC50:  45nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279142((Z)-2-(4-Methylphenyl)-5-(1H-pyrrolo[2,3-b]pyridin...)
Affinity DataIC50:  47nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279179((Z)-2-Morpholin-4-yl-5-[1-(1H-pyrrolo[2,3-b]pyridi...)
Affinity DataIC50:  47nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279182((Z)-2-[(3-Methylbenzyl)amino]-5-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM124950(US8765972, 3)
Affinity DataIC50:  50nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction in H2O2-induced PAR formation incubated for 30 mins followed by H2O2 addition for 15 mi...More data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279060((Z)-2-phenyl-5-(1Hpyrrolo[2,3-b]pyridin-3-ylmethyl...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279212((Z)-2-[(3-Bromobenzyl)amino]-5-(1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  55nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279141((Z)-2-Pyridin-3-yl-5-(1H-pyrrolo[2,3-b]pyridin-3-y...)
Affinity DataIC50:  60nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279282((Z)-2-[(cyclohexylmethyl)amino]-5-(1H-pyrrolo[2,3-...)
Affinity DataIC50:  64nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279181((Z)-2-(2-Methyl-morpholin-4-yl)-5-[1-(1H-pyrrolo[2...)
Affinity DataIC50:  66nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279211((Z)-2-[(4-Chlorobenzyl)amino]-5-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50:  86nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138354(US8877944, 105)
Affinity DataIC50:  90nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279099((Z)-2-(Benzylamino)-5-(1H-pyrrolo[2,3-b]pyridin-3-...)
Affinity DataIC50:  95nMAssay Description:Inhibition of Cdk9/cyclinT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138325(US8877944, 29)
Affinity DataIC50:  100nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279180((Z)-2-(4-Methyl-piperidin-1-yl)-5-[1-(1H-pyrrolo[2...)
Affinity DataIC50:  105nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138327(US8877944, 31)
Affinity DataIC50:  110nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279102((Z)-N-(3-{[2-(Benzylamino)-5-oxo-1,5-dihydro-4H-im...)
Affinity DataIC50:  116nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279213((Z)-2-[(4-Bromobenzyl)amino]-5-(1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  127nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279283((Z)-2-(Adamantylmethylamino)-5-(1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  128nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279100((Z)-2-(Benzylamino)-5-[(5-nitro-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  130nMAssay Description:Inhibition of Cdc7 (unknown origin)-mediated phosphorylation of Mcm2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138298(US8877944, 7)
Affinity DataIC50:  150nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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