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Found 1509 with Last Name = 'read' and Initial = 'm'
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266122(CHEMBL4070789)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged 15-PGDH expressed in Escherichia coli using PGE2 as substrate after 15 mins in presence of NA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266252(CHEMBL4061483)
Affinity DataKi:  0.100nMAssay Description:Inhibition of 15-PGDH (unknown origin) using PGE2 as substrate preincubated for 12 hrs followed by dialysis for 12 hrs and subsequent addition of NAD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266252(CHEMBL4061483)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to 15-PGDH (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50182468(4,6,2'-Trifluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)-...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50182464(2',4-difluoro-5'-[3-(trifluoromethyl)imidazo[1,2-b...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM18784(5-(3-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50179995(3'-(7-methyl-imidazo[1,2-a]pyrimidin-3-yl)-bipheny...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50179995(3'-(7-methyl-imidazo[1,2-a]pyrimidin-3-yl)-bipheny...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50179996(4,2'-difluoro-5'-(7-trifluoromethyl-imidazo[1,2-a]...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50179855(6,2'-Difluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)-imi...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50182464(2',4-difluoro-5'-[3-(trifluoromethyl)imidazo[1,2-b...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50179849(2-(3-(4-fluoro-3-(pyridin-3-yl)phenyl)imidazo[1,2-...)
Affinity DataKi:  0.850nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50182468(4,6,2'-Trifluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50064020(6-Ethyl-5-(3-methoxy-phenyl)-pyrimidine-2,4-diamin...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50179855(6,2'-Difluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)-imi...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha5 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50182467(3'-(3-methyl-imidazo[1,2-b][1,2,4]triazin-7-yl)bip...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50179996(4,2'-difluoro-5'-(7-trifluoromethyl-imidazo[1,2-a]...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50182465(4,2'-difluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)imid...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
LigandPNGBDBM50182467(3'-(3-methyl-imidazo[1,2-b][1,2,4]triazin-7-yl)bip...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50179855(6,2'-Difluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)-imi...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50179855(6,2'-Difluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)-imi...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha3 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50180005(1-(1-(3-(pyridin-3-yl)phenyl)-1H-benzo[d]imidazol-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50182465(4,2'-difluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)imid...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM18784(5-(3-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM18792(1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50179999(3'-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-biphenyl-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50179849(2-(3-(4-fluoro-3-(pyridin-3-yl)phenyl)imidazo[1,2-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50179999(3'-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-biphenyl-...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50192451(CHEMBL213053 | NADP+)
Affinity DataKi:  4.70nMAssay Description:Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50182466(3'-(7-methyl-imidazo[1,2-b]pyridazin-3-yl)-bipheny...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]Ro 15-1788 from recombinant human GABAA alpha1 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50064020(6-Ethyl-5-(3-methoxy-phenyl)-pyrimidine-2,4-diamin...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity against mutant Plasmodium falciparum DHFR-TSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50180005(1-(1-(3-(pyridin-3-yl)phenyl)-1H-benzo[d]imidazol-...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50064020(6-Ethyl-5-(3-methoxy-phenyl)-pyrimidine-2,4-diamin...)
Affinity DataKi:  14nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50192451(CHEMBL213053 | NADP+)
Affinity DataKi:  15nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50182466(3'-(7-methyl-imidazo[1,2-b]pyridazin-3-yl)-bipheny...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  33nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  72nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM18792(1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)
Affinity DataKi:  82nMAssay Description:Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS.More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239422(CHEMBL234346)
Affinity DataIC50:  0.0170nMAssay Description:Inhibition of SMAC-derived peptide abuRPFK (5 and 6FAM)-amide interaction with XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50234915(CHEMBL4069447)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human N-terminal His-GST-tagged TNKS2 (849 to 1166 residues) expressed in baculovirus infected Sf9 cells using biotinylated...More data for this Ligand-Target Pair
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450049(CHEMBL4166057)
Affinity DataIC50:  0.100nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50234915(CHEMBL4069447)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human N-terminal His-GST-tagged TNKS2 (849 to 1166 residues) expressed in baculovirus infected Sf9 cells using biotinylated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50234915(CHEMBL4069447)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450044(CHEMBL4167141)
Affinity DataIC50:  0.130nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450038(CHEMBL4171490)
Affinity DataIC50:  0.170nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450047(CHEMBL4169478)
Affinity DataIC50:  0.180nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450043(CHEMBL4166607)
Affinity DataIC50:  0.190nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50234916(CHEMBL4098188)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human N-terminal His-GST-tagged TNKS2 (849 to 1166 residues) expressed in baculovirus infected Sf9 cells using biotinylated...More data for this Ligand-Target Pair
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