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Found 97 with Last Name = 'reese' and Initial = 'h'
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026470((2-Hydroxy-ethyl)-dimethyl-sulfonium; iodide | CHE...)
Affinity DataKi:  4.00E+5nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026220(2-hydroxy-N,N,N-trimethylethanaminium | CHEMBL2824...)
Affinity DataKi:  4.00E+5nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026480(CHEMBL283149 | Trimethyl-sulfoniumoxide; iodide)
Affinity DataKi:  1.30E+6nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026468(CHEMBL25340 | Trimethyl-sulfonium; iodide)
Affinity DataKi:  2.00E+6nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026469(2-Trimethylsilanyl-ethanol | CHEMBL25482)
Affinity DataKi:  3.30E+6nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026475(Acetic acid 2-methanesulfonyl-ethyl ester | CHEMBL...)
Affinity DataKi:  6.40E+6nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026475(Acetic acid 2-methanesulfonyl-ethyl ester | CHEMBL...)
Affinity DataKi:  6.40E+6nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026468(CHEMBL25340 | Trimethyl-sulfonium; iodide)
Affinity DataKi:  7.20E+6nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026220(2-hydroxy-N,N,N-trimethylethanaminium | CHEMBL2824...)
Affinity DataKi:  7.60E+6nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026477(2-Methanesulfonyl-ethanol | CHEMBL281616)
Affinity DataKi:  8.70E+6nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026470((2-Hydroxy-ethyl)-dimethyl-sulfonium; iodide | CHE...)
Affinity DataKi:  1.30E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026478(5-dimethylamino-2-pentanone-N-oxide | CHEMBL25004)
Affinity DataKi:  1.40E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis of acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026474(3,3-Dimethyl-butan-1-ol | CHEMBL25029)
Affinity DataKi:  1.90E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026474(3,3-Dimethyl-butan-1-ol | CHEMBL25029)
Affinity DataKi:  1.90E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026472((CH3)2SO | (methanesulfinyl)methanedimethyl sulfox...)
Affinity DataKi:  2.50E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(com)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026473(CHEMBL25028 | Sulfonylbismethane | dimethyl sulfon...)
Affinity DataKi:  2.80E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026479(2-Methylsulfanyl-ethanol | CHEMBL277871)
Affinity DataKi:  4.00E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(com)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM36173(1-butanol | 1-butanol-d10 | CHEMBL14245)
Affinity DataKi:  4.70E+7nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(com)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026477(2-Methanesulfonyl-ethanol | CHEMBL281616)
Affinity DataKi:  1.00E+8nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(com)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine O-acetyltransferase(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50026473(CHEMBL25028 | Sulfonylbismethane | dimethyl sulfon...)
Affinity DataKi:  2.60E+8nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341350(2-(1-Acetyl-piperidin-4-ylamino)-6-(2,4-difluoroph...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341370(6-(2,4-Difluorophenoxy)-8-(1-methanesulfonyl-piper...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341361(6-(2,4-Difluorophenoxy)-8-ethyl-2-(tetrahydro-2H-p...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341366(6-(2,4-Difluorophenoxy)-8-(1,1-dioxo-hexahydro-thi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341363(6-(2,4-Difluorophenoxy)-8-(3-hydroxy-propyl)-2-(te...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341356(6-(2,4-Difluorophenoxy)-8-methyl-2-((S)-1-methyl-2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341369(CHEMBL1766506 | [6-(2,4-Difluorophenoxy)-7-oxo-2-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341352(CHEMBL1766580 | trans-6-(2,4-Difluorophenoxy)-2-(t...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341372(6-(2,4-Difluorophenoxy)-2-isopropylamino-8-methyl-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341346((R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methyls...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341365(6-(2,4-Difluorophenoxy)-8-(3-methanesulfonyl-propy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341368(6-(2,4-Difluorophenoxy)-8-((S)-2,3-dihydroxy-propy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341362(6-(2,4-Difluorophenoxy)-8-cyclopropyl-2-(tetrahydr...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341342(6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341358(6-(2,4-Difluoro-phenoxy)-8-methyl-2-((R)-1-methyl-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341367(6-(2,4-Difluorophenoxy)-8-(2-hydroxy-2-methyl-prop...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341349(6-(4-Fluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyra...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxy...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341353(6-(2-Fluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyra...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341354(2-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341360(6-(2,4-Difluorophenoxy)-8H-2-(tetrahydro-2H-pyran-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341364(6-(2,4-Difluorophenoxy)-8-(2-methanesulfonyl-ethyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341345(6-(2-Chlorophenyl)-8-methyl-2-(tetrahydro-2H-pyran...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341375(6-(2,4-Difluorophenoxy)-2-(2-hydroxy-1,1-dimethyl-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341373(6-(2,4-Difluorophenoxy)-8-methyl-2-[(S)-(tetrahydr...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341359(6-(2,4-Difluorobenzyl)-8-methyl-2-(tetrahydro-2H-p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341357(6-(2-Fluorobenzyl)-8-methyl-2-(tetrahydro-2H-pyran...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341348(6-(2,4-Difluorophenoxy)-2-((S)-2-methanesulfonyl-1...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341374(6-(2,4-Difluorophenoxy)-2-(2-hydroxy-2-methyl-prop...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341347(6-(Phenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylam...)
Affinity DataIC50:  106nMAssay Description:Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillatio...More data for this Ligand-Target Pair
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