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Found 174 with Last Name = 'ringer' and Initial = 't'
TargetCarboxypeptidase B(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50201438((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Affinity DataKi:  0.420nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase N catalytic chain(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50201438((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Affinity DataKi:  2nMAssay Description:Inhibition of human plasma carboxypeptidase NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197248(CHEMBL246244 | N-(2-methyl-2-phenylpropyl)-5,6,7,8...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197275(CHEMBL246023 | N-(2-(4-fluorophenyl)-2-methylpropy...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197249(CHEMBL245819 | N-(2-methyl-2-phenylpropyl)quinoxal...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197254(CHEMBL246250 | N-((1r,4r)-4-methylcyclohexyl)-5-(p...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50201438((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)
Affinity DataKi:  4nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197247(CHEMBL246251 | N-cycloheptyl-5-(piperidin-1-yl)pyr...)
Affinity DataKi:  8nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197268(5-(4-(hydroxymethyl)piperidin-1-yl)-N-((1r,4r)-4-m...)
Affinity DataKi:  9nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataKi:  10nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50109593(2-Benzyl-3-mercapto-propionic acid | 2-Mercaptomet...)
Affinity DataKi:  11nMAssay Description:Inhibition of bovine pancreatic carboxypeptidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197272(CHEMBL246245 | N-(2-methyl-2-phenylpropyl)-6-(pipe...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197276(5-((2-cyanoethyl)(methyl)amino)-N-(2-methyl-2-phen...)
Affinity DataKi:  14nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197266(CHEMBL246024 | N-(2-methoxy-2-phenylpropyl)quinoxa...)
Affinity DataKi:  15nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257637(1-(4-aminopyridin-2-yl)-4-phenyl-N-(quinolin-2-yl)...)
Affinity DataKi:  17nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197255(CHEMBL443489 | N-(2-methyl-2-phenylpropyl)-5-(pipe...)
Affinity DataKi:  17nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257723(2-(3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine...)
Affinity DataKi:  18nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197265(CHEMBL241699 | N-(2-phenylpropyl)quinoxaline-2-car...)
Affinity DataKi:  22nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197257(5-((1-(dimethylamino)propan-2-yl)(methyl)amino)-N-...)
Affinity DataKi:  27nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197270((R)-6-(2-hydroxy-1-phenylethylamino)-N-(2-methyl-2...)
Affinity DataKi:  27nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197251(6-(butyl(methyl)amino)-N-cycloheptylpyrazine-2-car...)
Affinity DataKi:  30nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257639((1-(4-aminopyridin-2-yl)-4-phenylpiperidin-4-yl)(3...)
Affinity DataKi:  35nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197264(5-(4-(hydroxymethyl)piperidin-1-yl)-N-(2-methyl-2-...)
Affinity DataKi:  35nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197252(CHEMBL247485 | N-(2,3-dihydro-1H-inden-2-yl)-6-(et...)
Affinity DataKi:  40nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197262(CHEMBL246025 | N-(2-methyl-2-(pyridin-2-yl)propyl)...)
Affinity DataKi:  40nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197245(CHEMBL393681 | N-(2-methyl-1-phenylpropan-2-yl)qui...)
Affinity DataKi:  40nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197267(6-((2-hydroxyethyl)(methyl)amino)-N-(2-methyl-2-ph...)
Affinity DataKi:  43nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197253(6-(3-hydroxyphenethylamino)-N-(cyclopropylmethyl)p...)
Affinity DataKi:  44nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226605((+/-)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl...)
Affinity DataKi:  46nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197259(6-(4-benzyl-1,4-diazepan-1-yl)-N-(cyclopropylmethy...)
Affinity DataKi:  56nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197271(CHEMBL245820 | N-phenethylquinoxaline-2-carboxamid...)
Affinity DataKi:  69nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226598((S)-2-(2-aminoethylamino)-3-(1-butyl-1H-imidazol-4...)
Affinity DataKi:  70nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257684(CHEMBL495346 | N-(1-(4-aminopyridin-2-yl)-4-phenyl...)
Affinity DataKi:  82nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226606((S)-2-(2-aminoethylamino)-3-(1-propyl-1H-imidazol-...)
Affinity DataKi:  84nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226597((S)-2-(2-aminoethylamino)-3-(1-isobutyl-1H-imidazo...)
Affinity DataKi:  100nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226611((S)-2-(2-aminoethylamino)-3-(1-(3-hydroxypropyl)-1...)
Affinity DataKi:  111nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226614((S)-2-(2-aminoethylamino)-3-(1-(cyclobutylmethyl)-...)
Affinity DataKi:  124nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197273((3-phenylpiperidin-1-yl)(quinoxalin-2-yl)methanone...)
Affinity DataKi:  125nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226613((S)-2-(2-aminoethylamino)-3-(1-phenethyl-1H-imidaz...)
Affinity DataKi:  140nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226607((+/-)-2-((1H-imidazol-4-yl)methyl)-5-aminopentanoi...)
Affinity DataKi:  140nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226602((S)-2-(2-aminoethylamino)-3-(1-pentyl-1H-imidazol-...)
Affinity DataKi:  160nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257638(CHEMBL493743 | ethyl 4-(1-(4-aminopyridin-2-yl)-4-...)
Affinity DataKi:  169nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197258(CHEMBL247476 | N-(2-methyl-2-phenylpropyl)-5-pheny...)
Affinity DataKi:  179nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257683(1-(4-aminopyridin-2-yl)-N-(4-methoxybenzyl)-4-phen...)
Affinity DataKi:  201nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Sus scrofa)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataKi:  206nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226601((2S)-2-[(2-aminoethyl)amino]-3-(1-methyl-1H-imidaz...)
Affinity DataKi:  235nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226599((S)-2-(2-aminoethylamino)-3-(1-ethyl-1H-imidazol-4...)
Affinity DataKi:  250nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226608((S)-2-(2-aminoethylamino)-3-(1-benzyl-1H-imidazol-...)
Affinity DataKi:  269nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226603((+/-)-5-amino-2-(mercaptomethyl)pentanoic acid | C...)
Affinity DataKi:  300nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197269(CHEMBL247475 | N-(2-methyl-2-phenylpropyl)-6-pheny...)
Affinity DataKi:  315nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalisation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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