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Found 781 with Last Name = 'roche' and Initial = 'c'
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015003(CHEMBL3262089 | US9259422, 7a, R = Ph-BU127 | US94...)
Affinity DataKi:  0.0440nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090755(CHEMBL3581743 | US9259422, 22, R = 4-FPh- BU10120 ...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090766(CHEMBL3581756)
Affinity DataKi:  0.0520nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090782(CHEMBL3581754)
Affinity DataKi:  0.0710nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090694(CHEMBL3581740 | US9259422, 22, R = Ph-BU128 | US94...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090694(CHEMBL3581740 | US9259422, 22, R = Ph-BU128 | US94...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50354578(BUPRENORPHINE | US10752592, Compound buprenorphine...)
Affinity DataKi:  0.0890nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090767(CHEMBL3581757)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090766(CHEMBL3581756)
Affinity DataKi:  0.0940nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090765(CHEMBL3581752)
Affinity DataKi:  0.0980nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090782(CHEMBL3581754)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090765(CHEMBL3581752)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090768(CHEMBL3581762)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090769(CHEMBL3581751)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090767(CHEMBL3581757)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50354578(BUPRENORPHINE | US10752592, Compound buprenorphine...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090768(CHEMBL3581762)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090773(CHEMBL3581753)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM85177(CAS_80558-61-8 | M&B-28767 | NSC_119139)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090755(CHEMBL3581743 | US9259422, 22, R = 4-FPh- BU10120 ...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090773(CHEMBL3581753)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015003(CHEMBL3262089 | US9259422, 7a, R = Ph-BU127 | US94...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090769(CHEMBL3581751)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM85603(CAS_5311503 | NSC_5311503 | ZK110841)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM35847((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Affinity DataKi:  0.330nMMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM85183(CAS_60325-46-4 | NSC_43251 | SULPROSTONE)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM85175(BW245C | CAS_72814-32-5 | NSC_3080928)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090782(CHEMBL3581754)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50085910((Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenox...)
Affinity DataKi:  0.470nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50090694(CHEMBL3581740 | US9259422, 22, R = Ph-BU128 | US94...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50354578(BUPRENORPHINE | US10752592, Compound buprenorphine...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cell membranes incubated for 1 hr by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50067735((6aR,10aR)-3-(1,1-Dimethyl-heptyl)-6,6,9-trimethyl...)
Affinity DataKi:  0.490nMAssay Description:Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCannabinoid receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287934((6aR,10aR)-3-(1,1-Dimethyl-heptyl)-6,6-dimethyl-9-...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM35847((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50067735((6aR,10aR)-3-(1,1-Dimethyl-heptyl)-6,6,9-trimethyl...)
Affinity DataKi:  0.830nMAssay Description:Binding affinity against human cannabinoid receptor by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM82213(CAS_41598-07-6 | NSC_114678 | PGD2)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM85603(CAS_5311503 | NSC_5311503 | ZK110841)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287941((6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetCannabinoid receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287934((6aR,10aR)-3-(1,1-Dimethyl-heptyl)-6,6-dimethyl-9-...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against human cannabinoid receptor by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCannabinoid receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287935(4-(1,1-Dimethyl-heptyl)-3',5'-dimethyl-biphenyl-2,...)
Affinity DataKi:  2nMAssay Description:Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCannabinoid receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287941((6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against human cannabinoid receptor by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetCannabinoid receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287930((6aR,10aR)-3-(1,1-Dimethyl-heptyl)-1-hydroxy-6,6-d...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against human cannabinoid receptor by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM85173(CAS_40666-16-8 | FLUPROSTENOL | NSC_5311100)
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287930((6aR,10aR)-3-(1,1-Dimethyl-heptyl)-1-hydroxy-6,6-d...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]-CP-55,940) assay.More data for this Ligand-Target Pair
In DepthDetails Article
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