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Found 240 with Last Name = 'ryder' and Initial = 'tr'
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071542((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-5-[2-(...)
Affinity DataKi:  82nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071543((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-4-oxo-...)
Affinity DataKi:  113nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071541((S)-3-(benzyloxycarbonylamino)-4-oxo-5-(3-phenylpr...)
Affinity DataKi:  4.50E+3nMAssay Description:Compound was tested for binding affinity against N-His (D381E) Interleukin -1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071543((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-4-oxo-...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (combinatorially prepared compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071542((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-5-[2-(...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (combinatorially prepared compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071543((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-4-oxo-...)
Affinity DataIC50:  7nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071542((S)-3-(2-Acetylamino-3-methyl-butyrylamino)-5-[2-(...)
Affinity DataIC50:  8nMAssay Description:Compound was tested for binding affinity against N-His (D381E) Interleukin -1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439246(CHEMBL2418830)
Affinity DataIC50:  17nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439247(CHEMBL2418831)
Affinity DataIC50:  21nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439245(CHEMBL2418991)
Affinity DataIC50:  22nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439247(CHEMBL2418831)
Affinity DataIC50:  23nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439244(CHEMBL2418829)
Affinity DataIC50:  24nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439246(CHEMBL2418830)
Affinity DataIC50:  30nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439245(CHEMBL2418991)
Affinity DataIC50:  33nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080037(Benzoic acid 4-((S)-2-{(S)-2-[(4-tert-butyl-benzyl...)
Affinity DataIC50:  36nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50078723((S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methy...)
Affinity DataIC50:  40nMAssay Description:In vitro antagonism of N-type voltage sensitive calcium channel in IMR-32 assay using fluorescent [Ca2+] indicator Indo-11 in the presence of 5 micro...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439244(CHEMBL2418829)
Affinity DataIC50:  47nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439243(CHEMBL2418998)
Affinity DataIC50:  50nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427899(CHEMBL2326090)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439241(CHEMBL2418999)
Affinity DataIC50:  70nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439242(CHEMBL2418828)
Affinity DataIC50:  80nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439242(CHEMBL2418828)
Affinity DataIC50:  85nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50078730((S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methy...)
Affinity DataIC50:  90nMAssay Description:In vitro antagonism of N-type voltage sensitive calcium channel in IMR-32 assay using fluorescent [Ca2+] indicator Indo-11 in the presence of 5 micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439243(CHEMBL2418998)
Affinity DataIC50:  100nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427903(CHEMBL2326087)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439241(CHEMBL2418999)
Affinity DataIC50:  120nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080046(Benzoic acid 4-((S)-2-{(S)-2-[(4-bromo-benzyl)-met...)
Affinity DataIC50:  130nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427904(CHEMBL2326086)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427911(CHEMBL2326095)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080305(Azepane-1-carboxylic acid (1-{4-[[4-(3,3-dimethyl-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439240(CHEMBL2418993)
Affinity DataIC50:  180nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080309(Azepane-1-carboxylic acid (1-{4-[(4-benzyloxy-phen...)
Affinity DataIC50:  190nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439238(CHEMBL2418995)
Affinity DataIC50:  190nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427903(CHEMBL2326087)
Affinity DataIC50:  190nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076117(Benzoic acid 4-{(S)-2-tert-butylcarbamoyl-2-[(S)-2...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory activity against N-type calcium channel in the IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439239(CHEMBL2418994)
Affinity DataIC50:  200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439237(CHEMBL2418996)
Affinity DataIC50:  200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBranched-chain-amino-acid aminotransferase, cytosolic(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172933(5-chloro-N'-(2-(trifluoromethyl)phenylsulfonyl)-1H...)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat BCATcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50078727((S)-2-(Cyclohexyl-methyl-amino)-4-methyl-pentanoic...)
Affinity DataIC50:  200nMAssay Description:In vitro antagonism of N-type voltage sensitive calcium channel in IMR-32 assay using fluorescent [Ca2+] indicator Indo-11 in the presence of 5 micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427909(CHEMBL2326097)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439236(CHEMBL2418997)
Affinity DataIC50:  210nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427900((R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]he...)
Affinity DataIC50:  223nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439239(CHEMBL2418994)
Affinity DataIC50:  230nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439240(CHEMBL2418993)
Affinity DataIC50:  230nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080035(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  230nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427913(CHEMBL2326093)
Affinity DataIC50:  230nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439238(CHEMBL2418995)
Affinity DataIC50:  240nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50427910(CHEMBL2326096)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50081687(Azepane-1-carboxylic acid ((S)-1-{2-[(4-benzyloxy-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-type calcium channels in IMR32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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