Affinity DataKi: 82nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
Affinity DataKi: 113nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
Affinity DataKi: 4.50E+3nMAssay Description:Compound was tested for binding affinity against N-His (D381E) Interleukin -1 beta converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (combinatorially prepared compound)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (combinatorially prepared compound)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Compound was tested for inhibitory activity against N-His (D381E) Interleukin -1 beta converting enzyme (resynthesized compound)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Compound was tested for binding affinity against N-His (D381E) Interleukin -1 beta converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:In vitro antagonism of N-type voltage sensitive calcium channel in IMR-32 assay using fluorescent [Ca2+] indicator Indo-11 in the presence of 5 micro...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:In vitro antagonism of N-type voltage sensitive calcium channel in IMR-32 assay using fluorescent [Ca2+] indicator Indo-11 in the presence of 5 micro...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:In vitro inhibitory activity against N-type calcium channel in the IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetBranched-chain-amino-acid aminotransferase, cytosolic(Rattus norvegicus)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of rat BCATcMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:In vitro antagonism of N-type voltage sensitive calcium channel in IMR-32 assay using fluorescent [Ca2+] indicator Indo-11 in the presence of 5 micro...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 223nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Institutes For Pharmaceutical Discovery
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert
Curated by ChEMBL
Warner-Lambert
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of N-type calcium channels in IMR32 human neuroblastoma cellsMore data for this Ligand-Target Pair