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Found 522 with Last Name = 'sall' and Initial = 'dj'
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075926(3-(3-Methoxy-4-pyrrolidin-1-ylmethyl-benzyl)-2-[4-...)
Affinity DataKi:  0.300nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443430(US10654866, Example 1B | US11117902, Example 1A | ...)
Affinity DataKi:  0.310nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  0.310nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443430(US10654866, Example 1B | US11117902, Example 1A | ...)
Affinity DataKi:  0.310nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  0.340nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443444(US10654866, Example 4B | US11117902, Example 4A | ...)
Affinity DataKi:  0.340nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443444(US10654866, Example 4B | US11117902, Example 4A | ...)
Affinity DataKi:  0.340nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075934(2-[4-(2-Amino-3-hydroxy-propoxy)-phenyl]-3-(3-meth...)
Affinity DataKi:  0.400nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075928(3-(3-Methoxy-4-pyrrolidin-1-ylmethyl-benzyl)-2-[6-...)
Affinity DataKi:  0.5nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075937(2-{4-[2-(2-Hydroxymethyl-pyrrolidin-1-yl)-ethoxy]-...)
Affinity DataKi:  0.5nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443449(US10654866, Example 3B | US11117902, Example 3A | ...)
Affinity DataKi:  0.590nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443449(US10654866, Example 3B | US11117902, Example 3A | ...)
Affinity DataKi:  0.590nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM518821(US11117902, Example 3B | US11634426, Example 3A)
Affinity DataKi:  0.590nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443450(US10654866, Example 4 | US11117902, Example 4 | US...)
Affinity DataKi:  0.640nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443450(US10654866, Example 4 | US11117902, Example 4 | US...)
Affinity DataKi:  0.640nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443450(US10654866, Example 4 | US11117902, Example 4 | US...)
Affinity DataKi:  0.640nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443434(US10654866, Example 2B | US11117902, Example 2A | ...)
Affinity DataKi:  0.650nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443433(US10654866, Example 2A | US11117902, Example 2B | ...)
Affinity DataKi:  0.650nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443433(US10654866, Example 2A | US11117902, Example 2B | ...)
Affinity DataKi:  0.650nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443428(Racemic 5-(4-{2-[3-(Fluoromethyl)azetidin-1-yl]eth...)
Affinity DataKi:  0.870nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443428(Racemic 5-(4-{2-[3-(Fluoromethyl)azetidin-1-yl]eth...)
Affinity DataKi:  0.870nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443428(Racemic 5-(4-{2-[3-(Fluoromethyl)azetidin-1-yl]eth...)
Affinity DataKi:  0.870nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075932(2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-N-{4-[...)
Affinity DataKi:  0.900nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075938(3-(3-Methoxy-4-pyrrolidin-1-ylmethyl-benzyl)-2-[4-...)
Affinity DataKi:  0.900nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443443(US10654866, Example 8B | US11117902, Example 8B | ...)
Affinity DataKi:  0.940nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443442(US10654866, Example 8A | US11117902, Example 8A | ...)
Affinity DataKi:  0.940nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443443(US10654866, Example 8B | US11117902, Example 8B | ...)
Affinity DataKi:  0.940nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443448(US10654866, Example 6B | US11117902, Example 6A | ...)
Affinity DataKi:  1.13nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443448(US10654866, Example 6B | US11117902, Example 6A | ...)
Affinity DataKi:  1.13nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443447(US10654866, Example 6A | US11117902, Example 6B | ...)
Affinity DataKi:  1.13nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443445(US10654866, Example 5A | US11117902, Example 5B | ...)
Affinity DataKi:  1.30nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443446(US10654866, Example 5B | US11117902, Example 5A | ...)
Affinity DataKi:  1.30nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443446(US10654866, Example 5B | US11117902, Example 5A | ...)
Affinity DataKi:  1.30nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443440(US10654866, Example 7 | US11634426, Example 7)
Affinity DataKi:  1.55nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM518852(US11117902, Example 7)
Affinity DataKi:  1.55nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443440(US10654866, Example 7 | US11634426, Example 7)
Affinity DataKi:  1.55nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075935(3-(3-Methyl-4-pyrrolidin-1-ylmethyl-benzyl)-2-[4-(...)
Affinity DataKi:  1.90nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075931(3-(3-BROMO-4-PYRROLIDIN-1-YLMETHYL-BENZYL)-2-[4-PY...)
Affinity DataKi:  2.10nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443432(Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...)
Affinity DataKi:  2.17nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443432(Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...)
Affinity DataKi:  2.17nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443432(Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]...)
Affinity DataKi:  2.17nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50075939(2-Dimethylamino-N-{4-[6-hydroxy-3-(3-methoxy-4-pyr...)
Affinity DataKi:  2.30nMAssay Description:Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443444(US10654866, Example 4B | US11117902, Example 4A | ...)
Affinity DataKi:  2.34nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  2.34nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443444(US10654866, Example 4B | US11117902, Example 4A | ...)
Affinity DataKi:  2.34nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443435(US10654866, Example 3 | US10654866, Example 3A | U...)
Affinity DataKi:  2.36nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443435(US10654866, Example 3 | US10654866, Example 3A | U...)
Affinity DataKi:  2.36nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443435(US10654866, Example 3 | US10654866, Example 3A | U...)
Affinity DataKi:  2.36nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  2.79nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443430(US10654866, Example 1B | US11117902, Example 1A | ...)
Affinity DataKi:  2.79nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
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