Found 126 with Last Name = 'sauer' and Initial = 'w' 
Affinity DataKi: 1nM ΔG°: -47.8kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -47.8kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -46.2kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -46.2kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -44.6kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -44.6kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -44.6kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -44.6kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 5nM ΔG°: -44.0kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 5nM ΔG°: -44.0kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 6nM ΔG°: -43.6kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 7nM ΔG°: -43.3kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -43.0kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -43.0kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -43.0kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 11nM ΔG°: -42.2kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 16nM ΔG°: -41.4kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 16nM ΔG°: -41.4kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 18nM ΔG°: -41.1kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 18nMpH: 5.5Assay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B at pH 5.5More data for this Ligand-Target Pair
Affinity DataKi: 20nM ΔG°: -40.8kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 25nM ΔG°: -40.3kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 43nM ΔG°: -39.1kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 46nM ΔG°: -38.9kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 53nM ΔG°: -38.6kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 54nM ΔG°: -38.6kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 77nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 91nM ΔG°: -37.4kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 652nM ΔG°: -32.8kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
Affinity DataKi: 1.07E+3nM ΔG°: -31.7kJ/molepH: 7.4 T: 2°CAssay Description:Receptor binding assay: Membranes were prepared from CHO cells expressing S1P1 or S1P3 for use in ligand and 35S-GTPgammaS binding studies. Cells wer...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 9nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 10nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 38nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 64nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 64nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 70nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 94nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human JNK3More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 189nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 202nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 314nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 355nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 377nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 575nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 612nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck Serono
US Patent
Merck Serono
US Patent
Affinity DataIC50: 630nMAssay Description:The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay.The assa...More data for this Ligand-Target Pair
