Affinity DataKi: 0.800nMAssay Description:Competitive reversible inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.880nMAssay Description:Binding affinity to recombinant human His6-tagged HDM2 (1 to 118 residues) assessed as reduction in PMDM6-F binding incubated for 15 to 30 mins by fl...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataKi: 1.79E+5nMAssay Description:Inhibition of PTP1B by fluorescein diphosphate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0780nMpH: 7.0 T: 2°CAssay Description:HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant DPP4 expressed in insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 0.230nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [654-1073](Homo sapiens (Human))
Merck Research Laboratories
Merck Research Laboratories
Affinity DataIC50: 0.270nMpH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...More data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 50 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.490nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.560nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair