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Found 373 with Last Name = 'scher' and Initial = 'l'
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  15nMAssay Description:Binding affinity to 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi:  76nMAssay Description:Binding affinity to adrenergic Alpha-1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  103nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  180nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to adrenergic alpha-1b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to beta2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50366826(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
Affinity DataKi:  2.49E+3nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50045000((NFLX)1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-...)
Affinity DataKi:  3.13E+3nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50045004(9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-ox...)
Affinity DataKi:  4.42E+3nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50226409(DEXTROFLOXACINE)
Affinity DataKi:  7.47E+4nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50366826(DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...)
Affinity DataKi:  9.96E+4nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50045000((NFLX)1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-...)
Affinity DataKi:  2.25E+5nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50045004(9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-ox...)
Affinity DataKi:  2.32E+5nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kansas University

Curated by ChEMBL
LigandPNGBDBM50226409(DEXTROFLOXACINE)
Affinity DataKi:  2.90E+5nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249488(4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323411(1-((1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)me...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50383959(CHEMBL2031999)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323406(1-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)met...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323405(1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-y...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50249488(4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit beta-1(Homo sapiens)
Neuromed Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50481476(CHEMBL599404)
Affinity DataIC50:  40nMAssay Description:Inhibition of N type calcium channel alpha-1b/alpha-2-delta-1/beta-1b expressed in HEK293 cells at holding potential of -100 mV by whole-cell patch c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50383948(CHEMBL2031983)
Affinity DataIC50:  40nMAssay Description:Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit beta-1(Homo sapiens)
Neuromed Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50481462(CHEMBL597782)
Affinity DataIC50:  40nMAssay Description:Inhibition of N type calcium channel alpha-1b/alpha-2-delta-1/beta-1b expressed in HEK293 cells at holding potential of -100 mV by whole-cell patch c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50481859(CHEMBL1088309)
Affinity DataIC50:  50nMAssay Description:Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit beta-1(Homo sapiens)
Neuromed Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50481477(CHEMBL599402)
Affinity DataIC50:  50nMAssay Description:Inhibition of N type calcium channel alpha-1b/alpha-2-delta-1/beta-1b expressed in HEK293 cells at holding potential of -100 mV by whole-cell patch c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit beta-1(Homo sapiens)
Neuromed Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50481448(CHEMBL605965)
Affinity DataIC50:  50nMAssay Description:Inhibition of N type calcium channel alpha-1b/alpha-2-delta-1/beta-1b expressed in HEK293 cells at holding potential of -100 mV by whole-cell patch c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50481859(CHEMBL1088309)
Affinity DataIC50:  50nMAssay Description:Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit beta-1(Homo sapiens)
Neuromed Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50481480(CHEMBL599829)
Affinity DataIC50:  60nMAssay Description:Inhibition of N type calcium channel alpha-1b/alpha-2-delta-1/beta-1b expressed in HEK293 cells at holding potential of -100 mV by whole-cell patch c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323411(1-((1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)me...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit beta-1(Homo sapiens)
Neuromed Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50481472(CHEMBL597585)
Affinity DataIC50:  70nMAssay Description:Inhibition of N type calcium channel alpha-1b/alpha-2-delta-1/beta-1b expressed in HEK293 cells at holding potential of -100 mV by whole-cell patch c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50184796(1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...)
Affinity DataIC50:  78nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017702(1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...)
Affinity DataIC50:  80nMAssay Description:Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit beta-1(Homo sapiens)
Neuromed Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50481475(CHEMBL598592)
Affinity DataIC50:  90nMAssay Description:Inhibition of N type calcium channel alpha-1b/alpha-2-delta-1/beta-1b expressed in HEK293 cells at holding potential of -100 mV by whole-cell patch c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50481860(CHEMBL1087660)
Affinity DataIC50:  90nMAssay Description:Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50481862(CHEMBL1087275)
Affinity DataIC50:  90nMAssay Description:Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50095765(1-(2,3,4-trimethoxybenzyl)-4-(bis(4-fluorophenyl)m...)
Affinity DataIC50:  90nMAssay Description:Blocking of rat N-type calcium channel alpha-1B/alpha-2-delta-1/beta-1b activity expressed in HEK293 cells assessed as whole cell current by whole ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50184796(1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...)
Affinity DataIC50:  96nMAssay Description:Inhibition of Smoothened transfected in HEK293 cells by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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