TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Competitive kinetic for thrombin inhibition Ki was determinedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Overall Inhibitory constant of the compound against thrombin was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 3.40nMAssay Description:In vitro reversible inhibition of thrombin catalytic activityMore data for this Ligand-Target Pair
Affinity DataKi: 4.71nMAssay Description:Inhibition of human factor 10a by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:Concentration of the compound required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 8.20nMAssay Description:Competitive kinetic for human alpha thrombin inhibition Ki was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Binding affinity for thrombin was reportedMore data for this Ligand-Target Pair
Affinity DataKi: 112nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 260nMAssay Description:Compound was evaluated for inhibition of human alpha-thrombin catalytic activityMore data for this Ligand-Target Pair
Affinity DataKi: 260nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
Affinity DataKi: 310nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 390nMAssay Description:Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
Affinity DataKi: 440nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
Affinity DataKi: 520nMAssay Description:Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO Beta-3 adrenergic receptor cell membrane.More data for this Ligand-Target Pair
Affinity DataKi: 590nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
Affinity DataKi: 760nMAssay Description:Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
Affinity DataKi: 806nMAssay Description:Effective concentration for stimulation of adenylyl cyclase activity in CHO-beta3 AR expressing cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 960nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 960nMAssay Description:Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
Affinity DataKi: 1.13E+3nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.15E+3nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.23E+3nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
Affinity DataKi: 1.25E+3nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.28E+3nMAssay Description:Inhibition of human TPA by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
Affinity DataKi: 1.96E+3nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.14E+3nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.25E+3nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.35E+3nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 3.28E+3nMAssay Description:Inhibition of human alpha-thrombin by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.44E+3nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
Affinity DataKi: 3.53E+3nMAssay Description:Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
Affinity DataKi: 3.68E+3nMAssay Description:Inhibition of human factor 7a by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.70E+3nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 6.30E+3nMAssay Description:Binding affinity to thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 6.40E+3nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 6.60E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 7.60E+3nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: >7.80E+3nMAssay Description:Inhibition of u-PAMore data for this Ligand-Target Pair
TargetChymotrypsinogen B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 9.42E+3nMAssay Description:Binding affinity to chymotrypsinMore data for this Ligand-Target Pair