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Found 915 with Last Name = 'seiler' and Initial = 'sm'
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107460((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  0.460nMAssay Description:Competitive kinetic for thrombin inhibition Ki was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50280255(7-Amino-3-{[(S)-1-((R)-2-amino-3-phenyl-propionyl)...)
Affinity DataKi:  1.70nMAssay Description:Overall Inhibitory constant of the compound against thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002132((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Affinity DataKi:  3.20nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50366780(BMS-189090 | CHEMBL138877)
Affinity DataKi:  3.40nMAssay Description:In vitro reversible inhibition of thrombin catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50358883(CHEMBL1923468)
Affinity DataKi:  4.71nMAssay Description:Inhibition of human factor 10a by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataKi:  7nMAssay Description:Concentration of the compound required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107463((S)-1-((R)-2-Methanesulfonylamino-3-phenyl-propion...)
Affinity DataKi:  8.20nMAssay Description:Competitive kinetic for human alpha thrombin inhibition Ki was determinedMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50039010((S)-2-[(S)-2-(4-Guanidino-butyrylamino)-3-phenyl-p...)
Affinity DataKi:  22nMAssay Description:Binding affinity for thrombin was reportedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289563(2-(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-eth...)
Affinity DataKi:  112nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287800(5-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  150nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289567(2-(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-eth...)
Affinity DataKi:  170nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002132((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Affinity DataKi:  170nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50287156(2-Benzyl-1H-indole-5-carboxamidine | CHEMBL287401)
Affinity DataKi:  260nMAssay Description:Compound was evaluated for inhibition of human alpha-thrombin catalytic activityMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289564((R)-1-(3-Chloro-phenyl)-2-{(R)-2-[4-(2-hydroxy-eth...)
Affinity DataKi:  260nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287796(CHEMBL308150 | ICI-215001 | {4-[2-((S)-2-Hydroxy-3...)
Affinity DataKi:  300nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289563(2-(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-eth...)
Affinity DataKi:  310nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287800(5-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  390nMAssay Description:Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287800(5-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  440nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287796(CHEMBL308150 | ICI-215001 | {4-[2-((S)-2-Hydroxy-3...)
Affinity DataKi:  520nMAssay Description:Compound was tested for its ability to stimulate adenylyl cyclase activity in CHO Beta-3 adrenergic receptor cell membrane.More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289567(2-(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-eth...)
Affinity DataKi:  590nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataKi:  630nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataKi:  630nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287799(4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  760nMAssay Description:Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073045((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Affinity DataKi:  806nMAssay Description:Effective concentration for stimulation of adenylyl cyclase activity in CHO-beta3 AR expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataKi:  960nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataKi:  960nMAssay Description:Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002133((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Affinity DataKi:  1.13E+3nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002132((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Affinity DataKi:  1.15E+3nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287795(3-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  1.23E+3nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289564((R)-1-(3-Chloro-phenyl)-2-{(R)-2-[4-(2-hydroxy-eth...)
Affinity DataKi:  1.25E+3nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50358883(CHEMBL1923468)
Affinity DataKi:  1.28E+3nMAssay Description:Inhibition of human TPA by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287799(4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  1.30E+3nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287799(4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  1.60E+3nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289563(2-(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-eth...)
Affinity DataKi:  1.96E+3nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289564((R)-1-(3-Chloro-phenyl)-2-{(R)-2-[4-(2-hydroxy-eth...)
Affinity DataKi:  2.14E+3nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073045((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Affinity DataKi:  2.25E+3nMAssay Description:Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287796(CHEMBL308150 | ICI-215001 | {4-[2-((S)-2-Hydroxy-3...)
Affinity DataKi:  2.35E+3nMAssay Description:Compound was tested for its binding affinity against beta2 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50358883(CHEMBL1923468)
Affinity DataKi:  3.28E+3nMAssay Description:Inhibition of human alpha-thrombin by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287795(3-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  3.44E+3nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287795(3-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-...)
Affinity DataKi:  3.53E+3nMAssay Description:Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligand...More data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50358883(CHEMBL1923468)
Affinity DataKi:  3.68E+3nMAssay Description:Inhibition of human factor 7a by Michaelis Menten equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289567(2-(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-eth...)
Affinity DataKi:  3.70E+3nMAssay Description:Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of t-PAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  6.30E+3nMAssay Description:Binding affinity to thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287798(4-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylam...)
Affinity DataKi:  6.40E+3nMAssay Description:Compound was tested for its binding affinity against Beta-1 adrenergic receptor in CHO cell membrane using [125I]-iodocyanopindolol as the radioligan...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073045((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Affinity DataKi:  7.60E+3nMAssay Description:Ability to bind to human Beta-1 adrenergic receptor using membranes of stably transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >7.80E+3nMAssay Description:Inhibition of u-PAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  9.42E+3nMAssay Description:Binding affinity to chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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