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Found 291 with Last Name = 'sellati' and Initial = 'r'
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Brutons tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257755(CHEMBL493537 | N-(5-((benzylamino)methyl)-1-(2-hyd...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257918(CHEMBL522682 | N-(5-((3,5-dimethylmorpholino)methy...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257855((R)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257857((S)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257803(CHEMBL521695 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257856((S)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257805(CHEMBL522871 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257806((R)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257699(CHEMBL493928 | N-(5-((cyclohexylamino)methyl)-1-(2...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257917(CHEMBL494027 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Protein tyrosine kinase LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374682(CHEMBL403154)
Affinity DataIC50:  2nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374683(CHEMBL258045)
Affinity DataIC50:  2nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257962(CHEMBL494743 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257855((R)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257858(CHEMBL492990 | N-(5-(((2-(dimethylamino)ethyl)(met...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257698(CHEMBL522849 | N-(5-((cyclohexyl(methyl)amino)meth...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257697(CHEMBL493319 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257804(CHEMBL495026 | N-(5-((sec-butylamino)methyl)-1-(2-...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257753(CHEMBL494135 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126739(2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-7-(3-pyr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126751(2-(2,6-Dichloro-phenylamino)-7-(3-ethylamino-prope...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126735(7-(3-Amino-propenyl)-2-(2,6-dichloro-phenylamino)-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374681(CHEMBL257834)
Affinity DataIC50:  2nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50275692(CHEMBL528989 | N-(1-(3-methoxypropyl)-5-((phenylam...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ITK (unknown origin) by DELPHIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257857((S)-N-(5-(((3,3-dimethylbutan-2-yl)(methyl)amino)m...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257754(CHEMBL494136 | N-(5-((dimethylamino)methyl)-1-(2-h...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257915(CHEMBL493007 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257916(CHEMBL493008 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126746(2-(2,6-Dichloro-phenylamino)-7-(3-dimethylamino-pr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374687(CHEMBL256194)
Affinity DataIC50:  3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257549(CHEMBL492931 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257806((R)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257918(CHEMBL522682 | N-(5-((3,5-dimethylmorpholino)methy...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374679(CHEMBL403258)
Affinity DataIC50:  3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257856((S)-N-(5-((3,3-dimethylbutan-2-ylamino)methyl)-1-(...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126749(2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-7-(3-mor...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257752(CHEMBL499219 | N-(5-(aminomethyl)-1-(2-hydroxy-2-m...)
Affinity DataIC50:  4nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374688(CHEMBL255991)
Affinity DataIC50:  4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374693(CHEMBL271309)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374684(CHEMBL270148)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374680(CHEMBL429504)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257803(CHEMBL521695 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human ITK expressed in BTK deficient DT40 cells assessed as inhibition of B cell receptor-stimulated calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50275651(CHEMBL487357 | N-(5-((cyclohexyl(methyl)amino)meth...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ITK (unknown origin) by DELPHIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374689(CHEMBL256196)
Affinity DataIC50:  7nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50257696(CHEMBL493318 | N-(1-(2-hydroxy-2-methylpropyl)-5-(...)
Affinity DataIC50:  8nMAssay Description:Binding affinity to ITK (unknown origin) by DELFIA-based molecular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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