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Found 246 with Last Name = 'settleman' and Initial = 'j'
TargetAurora kinase A-interacting protein(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of Aurora CMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  18nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of EGFR by cellular assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fes/Fps(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Affinity DataIC50:  1nMAssay Description:Inhibition of FesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of BmxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)
Affinity DataIC50:  3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)
Affinity DataIC50:  4nMAssay Description:Inhibition of c-YesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Lck by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81377(FIIN-1)
Affinity DataIC50:  6.20nM Kd:  6.90nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  8nMAssay Description:Inhibition of c-Met by cellular assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50:  9nMAssay Description:Inhibition of c-Met by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81377(FIIN-1)
Affinity DataIC50:  9.20nM Kd:  2.80nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81377(FIIN-1)
Affinity DataIC50:  11.9nM Kd:  5.40nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  12nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM50242740(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Affinity DataIC50:  13nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  20nMAssay Description:Inhibition of InsRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ALK by cellular assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  27nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)
Affinity DataIC50:  30nMAssay Description:Inhibition of c-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of FLT3 by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM6190(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Affinity DataIC50:  30nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human Her2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50:  68nMAssay Description:Inhibition of Ron by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)
Affinity DataIC50:  92nMAssay Description:Inhibition of EGFR by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337137(2-((2-methoxy-4-(4-(pyrrolidin-1-yl)piperidine-1-c...)
Affinity DataIC50:  130nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of FGFR1 by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81377(FIIN-1)
Affinity DataIC50:  189nM Kd:  120nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337127(2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino...)
Affinity DataIC50:  190nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337141(11-cyclopentyl-2-((2-methoxy-4-(4-methylpiperazin-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337139(11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of B-rafMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337131(2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperid...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Flk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)
Affinity DataIC50:  200nMAssay Description:Inhibition of c-Kit by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataIC50:  230nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337130(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)-5,11...)
Affinity DataIC50:  230nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337138(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  240nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337134(2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)ami...)
Affinity DataIC50:  240nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337128(2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)am...)
Affinity DataIC50:  240nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337132(2-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)ami...)
Affinity DataIC50:  260nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337129(2-((2-methoxy-4-morpholinophenyl)amino)-5,11-dimet...)
Affinity DataIC50:  260nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337133(5,11-dimethyl-2-((2-methyl-4-(4-methylpiperazin-1-...)
Affinity DataIC50:  280nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine--tRNA ligase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  286nMAssay Description:Inhibition of Syk by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  294nMAssay Description:Inhibition of AxlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Ron by cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337135(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  310nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337136(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  320nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81377(FIIN-1)
Affinity DataIC50:  381nM Kd:  65nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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