Compile Data Set for Download or QSAR
maximum 50k data
Found 2302 with Last Name = 'shah' and Initial = 'p'
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118030(4-(5-Cyclopropylaminomethyl-pyrazine-2-carbonyl)-3...)
Affinity DataKi:  0.0140nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228930((E)-2-(6-chloro-benzo[b]thiophen-2-yl)-ethenesulfo...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataKi:  0.160nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataKi:  0.160nM Kon:  4.90M-1s-1 Koff:  3.05E+4s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228950((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228676((S)-2-(5-chlorothiophen-2-yl)-N-(1-(4-(2-((dimethy...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306153((S)-2-(5-chlorothiophen-2-yl)-N-(1-(3-fluoro-2'-(m...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228676((S)-2-(5-chlorothiophen-2-yl)-N-(1-(4-(2-((dimethy...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374259(CHEMBL257741)
Affinity DataKi:  0.200nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataKi:  0.310nM Kon:  0.00000207M-1s-1 Koff:  6.63E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataKi:  0.310nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228954((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374264(CHEMBL257863)
Affinity DataKi:  0.400nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374262(CHEMBL272779)
Affinity DataKi:  0.400nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374270(CHEMBL271015)
Affinity DataKi:  0.5nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374263(CHEMBL437097)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50328712((S)-6-chloro-N-(1-(4-(2-((dimethylamino)methyl)-1H...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228940(6-chloro-N-(1-(4-(2-cyanopyridin-3-yl)-2-fluorophe...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306146((E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1S)-1...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306143(6-chloro-N-((S)-1-(4-((S)-1-(dimethylamino)ethyl)-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306142(6-chloro-N-((3S)-1-(4-(1-(ethyl(methyl)amino)ethyl...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306138(CHEMBL604887 | N-((3S)-1-(4-(1-(azetidin-1-yl)ethy...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374274(CHEMBL403111)
Affinity DataKi:  0.800nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12528((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12539((2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfona...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306146((E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1S)-1...)
Affinity DataKi:  1nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306140(6-chloro-N-((3S)-1-(2-fluoro-4-(1-(isopropylamino)...)
Affinity DataKi:  1nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12569(GTC000006A | N-(6-chloronaphthalen-2-yl)-N'-[(3S)-...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12557(6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12545((2S)-N-[2-(1H-azepin-1-yl)ethyl]-2-[(3S)-3-{2-[(6-...)
Affinity DataKi: <1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12544((2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfona...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12540((2S)-N-(2-aminoethyl)-2-[(3S)-3-{2-[(6-chloronapht...)
Affinity DataKi: <1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12541((2S)-N-[2-(carbamoylamino)ethyl]-2-[(3S)-3-{2-[(6-...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12542((2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfona...)
Affinity DataKi: <1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12543((2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfona...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228947(6-chloro-benzofuran-2-sulfonic acid [1-(3-fluoro-2...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228932(6-chloro-N-(1-(2-fluoro-4-(1-methyl-1H-imidazol-2-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374265(CHEMBL257862)
Affinity DataKi:  1.20nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306148((S)-4-(3-(2-(5-chlorothiophen-2-yl)vinylsulfonamid...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataKi:  1.70nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataKi:  1.73nM Kon:  0.0000109M-1s-1 Koff:  6.31E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228935((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12525((2S)-N-[2-(carbamoylamino)ethyl]-2-[(3S)-3-[(6-chl...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17654(5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12531((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12532((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12534((2S)-N-[2-(1H-azepin-1-yl)ethyl]-2-[(3S)-3-[(6-chl...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12535((2S)-N-(3-aminopropyl)-2-[(3S)-3-[(6-chloronaphtha...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12558(6-chloro-N-methyl-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(p...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12567(2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpho...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 2302 total ) | Next | Last >>
Jump to: