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Found 287 with Last Name = 'sharp' and Initial = 's'
TargetMineralocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228078((S)-N-(3-(1-cyclopropyl-1-(2,4-difluorophenyl)ethy...)
Affinity DataKi:  0.494nMAssay Description:Binding affinity to human mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228079((R)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi:  1.56nMAssay Description:Binding affinity to human mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228076((R)-N-(3-(1-cyclopropyl-1-(2,4-difluorophenyl)ethy...)
Affinity DataKi:  2.25nMAssay Description:Binding affinity to human mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228080(2',15'-dimethyl-5,5'-dioxo-(9'R)-spiro[tetrahydrof...)
Affinity DataKi:  2.32nMAssay Description:Binding affinity to human mineralocorticoid receptorMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228081((S)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to human mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228078((S)-N-(3-(1-cyclopropyl-1-(2,4-difluorophenyl)ethy...)
Affinity DataKi:  8.90nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPirin(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataKi:  28nMAssay Description:Inhibition of bisamide probe binding to pirin in human SKOV3 cells by SILAC-based quantitative mass spectrometry pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228080(2',15'-dimethyl-5,5'-dioxo-(9'R)-spiro[tetrahydrof...)
Affinity DataKi:  32.6nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228080(2',15'-dimethyl-5,5'-dioxo-(9'R)-spiro[tetrahydrof...)
Affinity DataKi:  39.4nMAssay Description:Binding affinity to human androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMineralocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228077(CHEMBL237122 | epierenone)
Affinity DataKi:  124nMAssay Description:Binding affinity to human mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228079((R)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi:  137nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228078((S)-N-(3-(1-cyclopropyl-1-(2,4-difluorophenyl)ethy...)
Affinity DataKi:  163nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228079((R)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi:  167nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPirin(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234079(CHEMBL4096048 | US9701664, Example 80)
Affinity DataKi:  190nMAssay Description:Inhibition of bisamide probe binding to pirin in human SKOV3 cells by SILAC-based quantitative mass spectrometry pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228081((S)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi:  313nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228081((S)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi:  387nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228080(2',15'-dimethyl-5,5'-dioxo-(9'R)-spiro[tetrahydrof...)
Affinity DataKi:  400nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228081((S)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi:  590nMAssay Description:Binding affinity to human androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228078((S)-N-(3-(1-cyclopropyl-1-(2,4-difluorophenyl)ethy...)
Affinity DataKi:  700nMAssay Description:Binding affinity to human androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228079((R)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi:  849nMAssay Description:Binding affinity to human androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228077(CHEMBL237122 | epierenone)
Affinity DataKi: >1.10E+3nMAssay Description:Binding affinity to human estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228080(2',15'-dimethyl-5,5'-dioxo-(9'R)-spiro[tetrahydrof...)
Affinity DataKi: >1.10E+3nMAssay Description:Binding affinity to human estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228079((R)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi: >1.10E+3nMAssay Description:Binding affinity to human estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228078((S)-N-(3-(1-cyclopropyl-1-(2,4-difluorophenyl)ethy...)
Affinity DataKi: >1.10E+3nMAssay Description:Binding affinity to human estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228081((S)-N-(3-(1-cyclopropyl-1-(4-fluorophenyl)ethyl)-1...)
Affinity DataKi: >1.10E+3nMAssay Description:Binding affinity to human estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228077(CHEMBL237122 | epierenone)
Affinity DataKi:  1.76E+3nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228077(CHEMBL237122 | epierenone)
Affinity DataKi:  8.89E+3nMAssay Description:Binding affinity to human androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50228077(CHEMBL237122 | epierenone)
Affinity DataKi:  2.94E+4nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234074(CHEMBL4070633 | US9701664, Example 39)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human U20S cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20927(4-{4-[(diethylamino)methyl]phenyl}-5-[2,4-dihydrox...)
Affinity DataIC50:  6nM EC50:  6nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20928(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50:  6nM EC50:  40nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20924(5-(5-tert-butyl-2,4-dihydroxyphenyl)-N-ethyl-4-[4-...)
Affinity DataIC50:  8nM EC50:  70nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20925(5-(5-tert-butyl-2,4-dihydroxyphenyl)-N-ethyl-4-[4-...)
Affinity DataIC50:  11nM EC50:  65nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234073(CHEMBL4063330 | US9701664, Example 1)
Affinity DataIC50:  12nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234073(CHEMBL4063330 | US9701664, Example 1)
Affinity DataIC50:  12nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20914(4-{4-[(diethylamino)methyl]phenyl}-N-ethyl-5-(5-et...)
Affinity DataIC50:  13nM EC50:  41nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20901(5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-{[(2...)
Affinity DataIC50:  14nM EC50:  1.98E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20919(5-(2,4-dihydroxy-5-phenylphenyl)-N-ethyl-4-[4-(pip...)
Affinity DataIC50:  14nM EC50:  86nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20921(5-[2,4-dihydroxy-5-(2-methylphenyl)phenyl]-N-ethyl...)
Affinity DataIC50:  14nM EC50:  114nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20930(Isoxazole, 70 | N-ethyl-5-(5-ethyl-2-hydroxy-4-met...)
Affinity DataIC50:  15nM EC50:  80nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20908(5-(5-chloro-2,4-dihydroxyphenyl)-4-{4-[(dimethylam...)
Affinity DataIC50:  18nM EC50:  69nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20905(5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(pip...)
Affinity DataIC50:  19nM EC50:  61nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataIC50:  19nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50234078(CHEMBL4087666 | US9701664, Example 63)
Affinity DataIC50:  19nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20915(Isoxazole, 40i | N-ethyl-5-{5-[2-(4-fluorophenyl)e...)
Affinity DataIC50:  20nM EC50:  39nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20900(5-(5-chloro-2,4-dihydroxyphenyl)-4-{4-[(1,1-dioxo-...)
Affinity DataIC50:  21nM EC50:  470nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50:  21nM EC50:  16nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20903(5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(mor...)
Affinity DataIC50:  21nM EC50:  83nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM20918(5-(2,4-dihydroxy-5-phenylphenyl)-N-ethyl-4-[4-(mor...)
Affinity DataIC50:  22nM EC50:  152nMAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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