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Found 1340 with Last Name = 'shaw' and Initial = 'kj'
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448761(CHEMBL3128021 | US8835445, 22)
Affinity DataKi:  0.00200nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17122(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.00400nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17127(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.00400nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17129(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.00400nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17135(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.00500nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17136(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.00500nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448757(CHEMBL3128025 | US8835445, 18)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17134(4-[(2-amino-1H-imidazol-1-yl)methyl]-3-chloro-N-{4...)
Affinity DataKi:  0.00600nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17111(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.00700nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448759(CHEMBL3128023 | US8835445, 17)
Affinity DataKi:  0.00700nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448758(CHEMBL3128024)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17137(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.00800nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17124(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0100nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17125(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0100nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17123(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0100nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17128(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0100nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17130(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0100nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17131(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0100nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17133(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0100nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448743(CHEMBL3128015)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448740(CHEMBL3128018)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448756(CHEMBL3128026 | US8835445, 21)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17112(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0120nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17118(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0120nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448741(CHEMBL3128017)
Affinity DataKi:  0.0190nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17104(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0190nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17138(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0200nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17107(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0200nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351175(CHEMBL1818127 | US8835445, 30)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17110(3-[({[4-chloro-5-({4-chloro-2-[(5-chloropyridin-2-...)
Affinity DataKi:  0.0220nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448753(CHEMBL3127912 | US8835445, 16)
Affinity DataKi:  0.0220nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17132(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0220nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448738(CHEMBL3127909)
Affinity DataKi:  0.0240nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17103(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0240nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17120(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0240nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351173(CHEMBL1818129 | US8835445, 40)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM50088963(7-{6-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-isopr...)
Affinity DataKi:  0.0260nMAssay Description:In vitro inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448751(CHEMBL3127914)
Affinity DataKi:  0.0260nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351174(CHEMBL1818128 | US8835445, 31)
Affinity DataKi:  0.0260nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17106(4-{[carbamoyl(methyl)amino]methyl}-3-chloro-N-{4-c...)
Affinity DataKi:  0.0260nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17119(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0260nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM50112518(3-(3-{2-Ethyl-6-[1-(1-imino-ethyl)-piperidin-4-ylo...)
Affinity DataKi:  0.0280nMAssay Description:Tested in vitro for the inhibitory potency against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448745(CHEMBL3128013 | US8835445, 26)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17117(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0310nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17126(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0340nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17109(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0360nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17105(3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...)
Affinity DataKi:  0.0450nMAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM50088944(7-{2-tert-Butyl-6-[1-(1-imino-ethyl)-piperidin-4-y...)
Affinity DataKi:  0.0460nMAssay Description:In vitro inhibitory activity against human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448739(CHEMBL3128019)
Affinity DataKi:  0.0480nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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