TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.0540nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.0580nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.0790nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.0870nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.0940nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.0990nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.140nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.510nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.520nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha/subunit beta-1/subunit beta-2(Mus musculus)
Daiichi Sankyo
Curated by ChEMBL
Daiichi Sankyo
Curated by ChEMBL
Affinity DataIC50: 0.550nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nM EC50: 2.40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.810nM EC50: 1.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.930nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
Affinity DataIC50: 1nM EC50: 1.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nM EC50: 0.590nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nM EC50: 0.550nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nM EC50: 1.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nM EC50: 0.910nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nM EC50: 7.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nM EC50: 1.10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2nM EC50: 5.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nM EC50: 1.80nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nM EC50: 0.900nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nM EC50: 0.720nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nM EC50: 0.720nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nM EC50: 0.650nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair