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Found 47 with Last Name = 'silverton' and Initial = 'jv'
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50010096(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Affinity DataKi:  0.180nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034872((S)-[4-(3-Fluoro-propyl)-phenyl]-hydroxy-phenyl-ac...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50010096(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Affinity DataKi:  0.220nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034875((S)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Affinity DataKi:  0.260nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034875((S)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Affinity DataKi:  0.310nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034874((R)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Affinity DataKi:  0.340nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034872((S)-[4-(3-Fluoro-propyl)-phenyl]-hydroxy-phenyl-ac...)
Affinity DataKi:  0.380nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034871((R)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Affinity DataKi:  0.840nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50011771(13-Methyl-10-thiiranyl-1,6,7,8,9,10,11,12,13,14,15...)
Affinity DataKi:  1nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE | NALORPHINE HYDROCHLORIDE)
Affinity DataKi:  2nMAssay Description:Compound administered subcutaneously was evaluated for inhibition constant measured as the displacement of [3H]DAGO from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034873((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  3.30nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034873((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  3.30nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034874((R)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Affinity DataKi:  4.20nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034870((S)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Affinity DataKi:  4.60nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50010096(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Affinity DataKi:  4.60nMAssay Description:In vitro binding affinity against against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034873((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  5.5nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034873((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  5.5nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50011774(13-Methyl-10-oxiranyl-1,6,7,8,9,10,11,12,13,14,15,...)
Affinity DataKi:  7nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034871((R)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Affinity DataKi:  7.60nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034874((R)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Affinity DataKi:  8.10nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034870((S)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034869((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  12nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034869((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  12nMAssay Description:In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034869((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  17.9nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic receptor M1(Bos taurus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034869((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  17.9nMAssay Description:In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50406525(CHEMBL2113272)
Affinity DataKi:  22nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034873((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  39nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034873((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi:  39nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034870((S)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Affinity DataKi:  41nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034872((S)-[4-(3-Fluoro-propyl)-phenyl]-hydroxy-phenyl-ac...)
Affinity DataKi:  59nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50011770(13-Methyl-10-thiiranyl-1,6,7,8,9,10,11,12,13,14,15...)
Affinity DataKi:  75nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50011775(13-Methyl-10-oxiranyl-1,6,7,8,9,10,11,12,13,14,15,...)
Affinity DataKi:  75nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50021778(3-(1,4a-Dimethyl-2,4a,5,6,7,7a-hexahydro-1H-[1]pyr...)
Affinity DataKi:  81nMAssay Description:Compound administered subcutaneously was evaluated for inhibition constant measured as the displacement of [3H]DAGO from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50021779(3-(4a-Ethyl-1-methyl-2,4a,5,6,7,7a-hexahydro-1H-[1...)
Affinity DataKi:  84nMAssay Description:Compound administered subcutaneously was evaluated for inhibition constant measured as the displacement of [3H]DAGO from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034875((S)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Affinity DataKi:  85nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50406524(CHEMBL2113269)
Affinity DataKi:  86nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50406523(CHEMBL2113276)
Affinity DataKi:  206nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50406522(CHEMBL2113268)
Affinity DataKi:  753nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034871((R)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034869((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50034869((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021347(CHEMBL12391 | N-(3-Methyl-1-phenethyl-piperidin-4-...)
Affinity DataIC50:  1.30nMAssay Description:In vivo binding affinity to opioid receptor preparations from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021347(CHEMBL12391 | N-(3-Methyl-1-phenethyl-piperidin-4-...)
Affinity DataIC50:  1.30nMAssay Description:In vivo binding affinity to opioid receptor preparations from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  25nMAssay Description:In vivo binding affinity to opioid receptor preparations from rat brainMore data for this Ligand-Target Pair
LigandPNGBDBM50226247(CHEMBL423449)
Affinity DataIC50:  96nMAssay Description:Binding affinity towards opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226268(CHEMBL348954)
Affinity DataIC50:  1.00E+3nMAssay Description:Binding affinity towards opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226243(CHEMBL353357)
Affinity DataIC50:  1.77E+3nMAssay Description:Binding affinity towards opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed