Compile Data Set for Download or QSAR
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Found 94 with Last Name = 'simon' and Initial = 'ja'
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

LigandPNGBDBM50239965(Bromhexine | CHEBI:77032)
Affinity DataIC50:  750nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

LigandPNGBDBM420291(0591-5329 | 4-(Methoxycarbonyl)phenyl thiophene-2-...)
Affinity DataIC50:  930nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

LigandPNGBDBM50022172((7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid meth...)
Affinity DataIC50:  1.37E+3nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59162(8047577)
Affinity DataIC50:  2.10E+3nMpH: 7.9Assay Description:Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59159(6190013)
Affinity DataIC50:  2.11E+3nMpH: 8.0Assay Description:Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59162(8047577)
Affinity DataIC50:  2.44E+3nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59162(8047577)
Affinity DataIC50:  2.56E+3nMpH: 8.0Assay Description:Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

LigandPNGBDBM420294(8008-1235 | N-[4-(4-chlorophenyl)-3-ethyl-1,3-thia...)
Affinity DataIC50:  2.64E+3nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

LigandPNGBDBM420292(4401-0077 | Antidepressant agent 1)
Affinity DataIC50:  2.68E+3nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50262769(CHEMBL4062161)
Affinity DataIC50:  3.26E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as decrease in peak tail current amplitude by path clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50262740(CHEMBL4074914)
Affinity DataIC50:  3.29E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as decrease in peak tail current amplitude by path clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50262771(CHEMBL4074997)
Affinity DataIC50:  3.38E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50262772(CHEMBL4085169)
Affinity DataIC50:  3.51E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as decrease in peak tail current amplitude by path clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59164(8048422)
Affinity DataIC50:  3.89E+3nMpH: 8.0Assay Description:Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59164(8048422)
Affinity DataIC50:  4.17E+3nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59154(5739991)
Affinity DataIC50:  4.63E+3nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59163(6789536)
Affinity DataIC50:  4.81E+3nMpH: 8.0Assay Description:Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59161(5738875)
Affinity DataIC50:  5.00E+3nMpH: 7.9Assay Description:Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50262768(CHEMBL4096279)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as decrease in peak tail current amplitude by path clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59163(6789536)
Affinity DataIC50:  5.60E+3nMpH: 7.9Assay Description:Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59161(5738875)
Affinity DataIC50:  5.65E+3nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59163(6789536)
Affinity DataIC50:  5.85E+3nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50004764(CHEMBL3233733)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of SIRT3 (unknown origin) by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59165(8056354)
Affinity DataIC50:  6.29E+3nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59165(8056354)
Affinity DataIC50:  6.51E+3nMpH: 8.0Assay Description:Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59153(5737176)
Affinity DataIC50:  6.66E+3nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59164(8048422)
Affinity DataIC50:  6.70E+3nMpH: 7.9Assay Description:Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59165(8056354)
Affinity DataIC50:  6.80E+3nMpH: 7.9Assay Description:Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59161(5738875)
Affinity DataIC50:  6.83E+3nMpH: 8.0Assay Description:Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59159(6190013)
Affinity DataIC50:  7.50E+3nMpH: 7.9Assay Description:Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59159(6190013)
Affinity DataIC50:  8.48E+3nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59153(5737176)
Affinity DataIC50:  8.50E+3nMpH: 7.9Assay Description:Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146058(Benzo[de]isochromene-1,3-dione | CHEMBL316059)
Affinity DataIC50:  8.80E+3nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59153(5737176)
Affinity DataIC50:  9.25E+3nMpH: 8.0Assay Description:Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59154(5739991)
Affinity DataIC50:  1.04E+4nMpH: 8.0Assay Description:Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59154(5739991)
Affinity DataIC50:  1.17E+4nMpH: 7.9Assay Description:Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59157(6126765)
Affinity DataIC50:  1.19E+4nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146048(2,3-Dihydro-1H-naphtho[2,1-b]oxepin-4-one | CHEMBL...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59160(6209549)
Affinity DataIC50:  1.24E+4nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50262767(CHEMBL4101606)
Affinity DataIC50:  1.24E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as decrease in peak tail current amplitude by path clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50004887(CHEMBL3233749)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of SIRT2 (unknown origin) by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50262770(CHEMBL4101684)
Affinity DataIC50:  2.01E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as decrease in peak tail current amplitude by path clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50004795(CHEMBL3233748)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of C-terminal His-6-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59155(5924029)
Affinity DataIC50:  2.45E+4nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146067(1,2-Dihydro-benzo[f]thiochromen-3-one | CHEMBL3143...)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50004777(CHEMBL3233742)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of C-terminal His-6-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VIII(Homo sapiens (Human))
University of Washington

LigandPNGBDBM59156(6072484 | cid_726942)
Affinity DataIC50:  2.68E+4nMT: 2°CAssay Description:Inhibition of factor VIII C2 domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146063(2-Isobutyl-1,2-dihydro-benzo[f]chromen-3-one | CHE...)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146044(2-Allyl-1,2-dihydro-benzo[f]chromen-3-one | CHEMBL...)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146052(5-Benzyloxy-1,2-dihydro-benzo[f]chromen-3-one | CH...)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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