Compile Data Set for Download or QSAR
maximum 50k data
Found 556 with Last Name = 'smith' and Initial = 'dg'
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8336(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Affinity DataKi:  0.0800nM ΔG°:  -57.1kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8337(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.110nM ΔG°:  -56.3kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8339(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287729(3-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-ph...)
Affinity DataKi:  0.400nMAssay Description:inhibition of [125I]-SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17156(3-(4-{[3-(3-methoxy-4-{[(2-methylphenyl)carbamoyl]...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17156(3-(4-{[3-(3-methoxy-4-{[(2-methylphenyl)carbamoyl]...)
Affinity DataKi:  0.501nM ΔG°:  -52.5kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17175((3R)-3-(4-{[3-(2-chloro-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  0.790nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17169((3R)-3-(4-{[3-(3-methoxy-4-{[(2-methylphenyl)carba...)
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17196((3R)-3-{4-[2-(3-methoxy-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8338(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.950nM ΔG°:  -51.0kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17167((3R)-3-(4-{[3-(4-{[(2-methylphenyl)carbamoyl]amino...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17174((3R)-3-(4-{[3-(3-methyl-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  1nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17170((3R)-3-(4-{[3-(3-chloro-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  1nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17168((3S)-3-(4-{[3-(3-methoxy-4-{[(2-methylphenyl)carba...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17154(3-{4-[(3-{3-methoxy-4-[(phenylcarbamoyl)amino]phen...)
Affinity DataKi:  1.58nM ΔG°:  -49.7kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17172((3R)-3-(4-{[3-(3-ethoxy-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  2nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17164(3-(4-{[3-(4-{[(2,6-dimethylphenyl)carbamoyl]amino}...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17177((3S)-3-(4-{[3-(3-chloro-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  2nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17165(3-(4-{[3-(4-{[(2-methylphenyl)carbamoyl]amino}phen...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50085043(3-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-ph...)
Affinity DataKi:  2.5nMAssay Description:inhibition of [125I]-SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50085043(3-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-ph...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [125I]-SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17176((3R)-3-(4-{[3-(2-methyl-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  2.51nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17181((3S)-3-(4-{[3-(3-methyl-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  2.51nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17165(3-(4-{[3-(4-{[(2-methylphenyl)carbamoyl]amino}phen...)
Affinity DataKi:  2.51nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17166((3S)-3-(4-{[3-(4-{[(2-methylphenyl)carbamoyl]amino...)
Affinity DataKi:  2.51nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]-ABP688 from human mGluR5 expressed in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17191(3-(3-{[3-(4-{[(2-methylphenyl)carbamoyl]amino}phen...)
Affinity DataKi:  3.98nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17171((3R)-3-(4-{[3-(4-{[(2-methylphenyl)carbamoyl]amino...)
Affinity DataKi:  3.98nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8337(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  5nM ΔG°:  -46.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8336(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Affinity DataKi:  5nM ΔG°:  -46.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17179((3S)-3-(4-{[3-(3-ethoxy-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  5.01nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17159(3-(4-{[3-(4-{[(2-bromophenyl)carbamoyl]amino}-3-me...)
Affinity DataKi:  5.01nM ΔG°:  -46.9kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17173((3R)-3-(4-{[3-(3-ethyl-4-{[(2-methylphenyl)carbamo...)
Affinity DataKi:  6.31nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17160(3-(4-{[3-(4-{[(2-acetamidophenyl)carbamoyl]amino}-...)
Affinity DataKi:  6.31nM ΔG°:  -46.3kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17158(3-(4-{[3-(3-methoxy-4-{[(2-methoxyphenyl)carbamoyl...)
Affinity DataKi:  6.31nM ΔG°:  -46.3kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17163(3-(4-{[3-(4-{[(2,5-dimethylphenyl)carbamoyl]amino}...)
Affinity DataKi:  7.94nM ΔG°:  -45.8kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataKi:  9.10nM ΔG°:  -45.4kJ/mole IC50:  34.3nMpH: 7.0 T: 2°CAssay Description:In vitro kinase inhibition assay using purified GSK-3 alpha from insect cells, was incubated at room temperature with substrate, and test compounds i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287732(3-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-ph...)
Affinity DataKi:  15nMAssay Description:inhibition of [125I]-SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17183((3S)-3-(4-{[3-(2-methyl-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  19.9nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17178((3S)-3-(4-{[3-(4-{[(2-methylphenyl)carbamoyl]amino...)
Affinity DataKi:  19.9nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50049244(5-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-be...)
Affinity DataKi:  22nMAssay Description:inhibition of [125I]-SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50049244(5-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-be...)
Affinity DataKi:  22nMAssay Description:Inhibition of [125I]-SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17161(3-(4-{[3-(4-{[(2,3-dimethylphenyl)carbamoyl]amino}...)
Affinity DataKi:  25.1nM ΔG°:  -42.9kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17188(3-(4-{[3-(3-methoxy-4-{[(2-methylphenyl)carbamoyl]...)
Affinity DataKi:  25.1nM ΔG°:  -42.9kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17182((3S)-3-(4-{[3-(2-chloro-4-{[(2-methylphenyl)carbam...)
Affinity DataKi:  25.1nMAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17162(3-(4-{[3-(4-{[(2,4-dimethylphenyl)carbamoyl]amino}...)
Affinity DataKi:  25.1nM ΔG°:  -42.9kJ/molepH: 7.5 T: 2°CAssay Description:J6 cells (1 million cells/well) were allowed to coat wheat germ agglutinin coated SPA beads (Amersham, 1 mg/well) in assay buffer. Tritiated 3H Stand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287733(2-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-be...)
Affinity DataKi:  30nMAssay Description:Inhibition of [125I]-SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50429412(CHEMBL2338582)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-ABP688 from human mGluR5 expressed in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8297(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophen...)
Affinity DataKi:  30.8nM ΔG°:  -42.4kJ/mole IC50:  77.5nMpH: 7.0 T: 2°CAssay Description:In vitro kinase inhibition assay using purified GSK-3 alpha from insect cells, was incubated at room temperature with substrate, and test compounds i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287727(3-{4-[2-(Benzooxazol-2-yl-methyl-amino)-ethoxy]-ph...)
Affinity DataKi:  33nMAssay Description:inhibition of [125I]-SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails Article
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