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Found 167 with Last Name = 'soares' and Initial = 'p'
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50504743(CHEMBL4464272)
Affinity DataKi:  21nMAssay Description:Competitive inhibition of human microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as inhibition constant using kynuramin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50504739(CHEMBL4585553)
Affinity DataKi:  44nMAssay Description:Competitive inhibition of human microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as inhibition constant using kynuramin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50504740(CHEMBL4514572)
Affinity DataKi:  75nMAssay Description:Competitive inhibition of human microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as inhibition constant using kynuramin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Escherichia coli)
University Of Adelaide

Curated by ChEMBL
LigandPNGBDBM50039492(CHEMBL1231498)
Affinity DataKi:  87nMAssay Description:Inhibition of Escherichia coli recombinant BPL using 3H-biotin as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Adelaide

LigandPNGBDBM92383(Biotin triazole, 14)
Affinity DataKi:  90nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388931(CHEMBL2063402)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50039492(CHEMBL1231498)
Affinity DataKi:  182nMAssay Description:Inhibition of human recombinant BPL using 3H-biotin as substrate after 10 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388933(CHEMBL2063403)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Adelaide

LigandPNGBDBM92378(Biotin triazole, 5)
Affinity DataKi:  1.17E+3nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Adelaide

LigandPNGBDBM92382(Biotin triazole, 13)
Affinity DataKi:  1.17E+3nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388934(CHEMBL2063404)
Affinity DataKi:  3.50E+3nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388927(CHEMBL2063398)
Affinity DataKi:  3.85E+3nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388932(CHEMBL2062535)
Affinity DataKi:  6.43E+3nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Adelaide

LigandPNGBDBM92379(Biotin triazole, 10)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Adelaide

LigandPNGBDBM92385(Biotin triazole, 16)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Adelaide

LigandPNGBDBM92381(Biotin triazole, 12)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Adelaide

LigandPNGBDBM92384(Biotin triazole, 15)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
University Of Adelaide

LigandPNGBDBM92380(Biotin triazole, 11)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro enzyme inhibition using biotin protein ligase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388935(CHEMBL2063405)
Affinity DataKi:  1.20E+4nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388930(CHEMBL2063401)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388929(CHEMBL2063400)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin--protein ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388928(CHEMBL2063399)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]-biotin from human BPL after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534432(CHEMBL4463709)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108877((3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone |...)
Affinity DataIC50:  0.910nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108877((3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone |...)
Affinity DataIC50:  0.912nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534437(CHEMBL4437043)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534438(CHEMBL4447349)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534438(CHEMBL4447349)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human microsomal MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in 4-hydroxyquinoline formation using...More data for this Ligand-Target Pair
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534433(CHEMBL4448310)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  3.47nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534435(CHEMBL4543735)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534435(CHEMBL4543735)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534434(CHEMBL4444830)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534434(CHEMBL4444830)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50479610(CHEMBL481644)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50479610(CHEMBL481644)
Affinity DataIC50:  5nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534436(CHEMBL4437795)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50479631(CHEMBL137555)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534437(CHEMBL4437043)
Affinity DataIC50:  11nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534432(CHEMBL4463709)
Affinity DataIC50:  13nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50479631(CHEMBL137555)
Affinity DataIC50:  13nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in 4-hydroxyquinoline formation using...More data for this Ligand-Target Pair
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534433(CHEMBL4448310)
Affinity DataIC50:  30nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108877((3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone |...)
Affinity DataIC50:  31nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  34nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in 4-hydroxyquinoline formation using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50504739(CHEMBL4585553)
Affinity DataIC50:  47nMAssay Description:Inhibition of human microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in 4-hydroxyquinoline formation using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50534438(CHEMBL4447349)
Affinity DataIC50:  52nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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