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Found 189 with Last Name = 'sobolev' and Initial = 'ap'
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM21125((5S,8R,10Z,13R)-13-[(2S)-2-amino-3-(4-hydroxypheny...)
Affinity DataKi:  0.430nM ΔG°:  -53.5kJ/mole EC50:  0.830nMpH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universita Degli Studi

LigandPNGBDBM21129((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  0.550nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM21126((5S,8R,10E,13R)-13-[(2S)-2-amino-3-(4-hydroxypheny...)
Affinity DataKi:  0.570nM ΔG°:  -52.8kJ/mole EC50:  0.880nMpH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM21129((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  0.822nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universita Degli Studi

LigandPNGBDBM21126((5S,8R,10E,13R)-13-[(2S)-2-amino-3-(4-hydroxypheny...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/mole EC50:  2.65nMpH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universita Degli Studi

LigandPNGBDBM21125((5S,8R,10Z,13R)-13-[(2S)-2-amino-3-(4-hydroxypheny...)
Affinity DataKi:  1.35nM ΔG°:  -50.6kJ/mole EC50:  2.35nMpH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM21008((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  1.60nM ΔG°:  -50.2kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143988(CHEMBL3759518)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM95979(2-[2-(2,4-dichlorophenyl)-2-keto-ethyl]-1,1-diketo...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143989(CHEMBL3759567)
Affinity DataKi:  3.90nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143991(CHEMBL3758428)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143993(CHEMBL3758979)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143990(CHEMBL3759876)
Affinity DataKi:  4.10nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143902(CHEBI:74235 | CHEMBL79350)
Affinity DataKi:  4.10nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM16417((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic aci...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143986(CHEMBL3758420)
Affinity DataKi:  4.30nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143980(CHEMBL3758923)
Affinity DataKi:  4.30nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143979(CHEMBL3759331)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143985(CHEMBL3758373)
Affinity DataKi:  4.5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143977(CHEMBL3760060)
Affinity DataKi:  4.70nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143984(CHEMBL3759099)
Affinity DataKi:  4.90nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143943(CHEMBL3759375)
Affinity DataKi:  5.10nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143992(CHEMBL3760113)
Affinity DataKi:  5.5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143987(CHEMBL3760047)
Affinity DataKi:  5.60nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143982(CHEMBL3759447)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM21127((5S,8R,13R)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  7.90nM ΔG°:  -46.2kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM21128((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataKi:  8.10nM ΔG°:  -46.2kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143905(CHEMBL3759443)
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143904(CHEMBL1489759)
Affinity DataKi:  16nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143907(CHEMBL3759629)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143993(CHEMBL3758979)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143907(CHEMBL3759629)
Affinity DataKi:  19nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143979(CHEMBL3759331)
Affinity DataKi:  19nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143980(CHEMBL3758923)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143983(CHEMBL1391313)
Affinity DataKi:  23nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  25nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143906(CHEMBL3758327)
Affinity DataKi:  26nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143991(CHEMBL3758428)
Affinity DataKi:  26nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143990(CHEMBL3759876)
Affinity DataKi:  27nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143981(CHEMBL3759882)
Affinity DataKi:  29nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50397109(CHEMBL2171847)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor transfected in human HN9.10 cells after 3 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143983(CHEMBL1391313)
Affinity DataKi:  41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143978(CHEMBL3759608)
Affinity DataKi:  41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143903(CHEMBL3125555)
Affinity DataKi:  42nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Universita Degli Studi

LigandPNGBDBM21129((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  44.9nM ΔG°:  -41.9kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50143977(CHEMBL3760060)
Affinity DataKi:  51nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Universita Degli Studi

LigandPNGBDBM21127((5S,8R,13R)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  56.9nM ΔG°:  -41.4kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50397110(CHEMBL2171846)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor transfected in human HN9.10 cells after 3 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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