Compile Data Set for Download or QSAR
maximum 50k data
Found 440 with Last Name = 'staels' and Initial = 'b'
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50234375((S)-2-ethoxy-3-(4-(2-(6-((methoxyimino)(phenyl)met...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50294690((S)-2-ethoxy-3-(4-(2-(6-((methoxyimino)(phenyl)met...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM28798((2S)-2-ethoxy-3-(4-{2-[4-(methanesulfonyloxy)pheny...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50294688((S)-3-(4-(2-(6-((benzyloxyimino)(phenyl)methyl)-4,...)
Affinity DataKi:  18.4nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50294692((S)-3-(4-(2-(6-((methoxyimino)(phenyl)methyl)-4,4-...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50234377(2-ethoxy-3-(4-(2-(6-((methoxyimino)(phenyl)methyl)...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50294691((S)-2-(2-benzoylphenylamino)-3-(4-(2-(6-((methoxyi...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50294689((S)-3-(4-(2-(6-((allyloxyimino)(phenyl)methyl)-4,4...)
Affinity DataKi:  54.2nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50234372((R)-2-ethoxy-3-(4-(2-(6-((methoxyimino)(phenyl)met...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50294693((S)-3-(4-(2-(6-((cyclopropylmethoxyimino)(phenyl)m...)
Affinity DataKi:  254nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50234373(CHEMBL253851 | ethyl 2-ethoxy-3-(4-(2-(6-((hydroxy...)
Affinity DataKi:  618nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50234379(CHEMBL252995 | dimethyl 2-(4-(2-(6-benzoyl-4,4-dim...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50294694((S)-2-(2-ethoxy-2-oxoethylamino)-3-(4-(2-(6-((hydr...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50234376(CHEMBL252996 | dimethyl 2-(4-(2-(6-((hydroxyimino)...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50294695((S)-2-acetoxy-3-(4-(2-(6-((methoxyimino)(phenyl)me...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]rosiglitazone from human PPARgamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50234374((S)-ethyl 2-ethoxy-3-(4-(2-(6-((methoxyimino)(phen...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50234378(CHEMBL399629 | ethyl 2-ethoxy-3-(4-(2-(6-((methoxy...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]Rosiglitazone from human PPARgammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human ACE-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005638(CHEMBL3235414)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005640(CHEMBL3235415)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005637(CHEMBL3235413)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005636(CHEMBL3235412)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (1 to 40) hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer a...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005646(CHEMBL3235419)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005645(CHEMBL3235418)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005643(CHEMBL3235417)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant ECE1-mediated amyloid beta hydrolysis after 45 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ACE-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant ACE2-mediated amyloid beta hydrolysis using Mca-Tyr-Val-Ala-Asp-Pro-Ala-Lys-(DNP)-OH as substrate after 20 mins by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP13-mediated amyloid beta hydrolysis after 10 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP1-mediated amyloid beta hydrolysis using DNP-Pro-Cha-Gly- Cys(Me)-His-Ala- Lys(n-Me-Abz)-NH2 as substrate after 40...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant TACE-mediated amyloid beta hydrolysis after 5 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataEC50:  530nMAssay Description:Induction of human recombinant IDE-mediated insulin hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50171895((2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid | (...)
Affinity DataEC50:  700nMAssay Description:Effective concentration against human PPARalpha expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Università

Curated by ChEMBL
LigandPNGBDBM28759((2S)-3-phenyl-2-(4-phenylphenoxy)propanoic acid | ...)
Affinity DataEC50:  0.200nMAssay Description:Effective concentration against murine PPARalpha in transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50171896((S)-2-(4-Hydroxymethyl-phenoxy)-3-phenyl-propionic...)
Affinity DataEC50:  2.57E+4nMAssay Description:Effective concentration against human PPARgamma expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM28759((2S)-3-phenyl-2-(4-phenylphenoxy)propanoic acid | ...)
Affinity DataEC50:  500nMAssay Description:Effective concentration against human PPARalpha expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50171897((2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid | ...)
Affinity DataEC50:  3.90E+3nMAssay Description:Effective concentration against human PPARalpha expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50171899((S)-2-(4'-Chloro-biphenyl-4-ylmethoxy)-pentanoic a...)
Affinity DataEC50:  3.90E+3nMAssay Description:Effective concentration against human PPARalpha expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50171898((S)-3-Phenyl-2-(4-trifluoromethyl-phenoxy)-propion...)
Affinity DataEC50:  900nMAssay Description:Effective concentration against human PPARgamma expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50171900((S)-3-Phenyl-2-(4-thiophen-2-yl-phenoxy)-propionic...)
Affinity DataEC50:  1.60E+3nMAssay Description:Effective concentration against human PPARgamma expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM28699(2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...)
Affinity DataEC50:  3.09E+5nMAssay Description:Effective concentration against human PPARgamma expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50171901((R)-2-(Naphthalen-2-yloxy)-pentanoic acid | CHEMBL...)
Affinity DataEC50:  1.25E+4nMAssay Description:Effective concentration against human PPARgamma expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Spot-Ea3857

Curated by ChEMBL
LigandPNGBDBM50171902((S)-2-(Naphthalen-2-yloxy)-pentanoic acid | CHEMBL...)
Affinity DataEC50:  7.20E+3nMAssay Description:Effective concentration against human PPARgamma expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50171903((S)-2-(Naphthalen-2-yloxy)-3-phenyl-propionic acid...)
Affinity DataEC50:  1.40E+3nMAssay Description:Effective concentration against human PPARalpha expressed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM28699(2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...)
Affinity DataEC50:  3.96E+4nMAssay Description:Effective concentration against human PPARalpha expressed in HepG2 cellsMore data for this Ligand-Target Pair
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