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Found 322 with Last Name = 'sylvain' and Initial = 'c'
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50249090(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)
Affinity DataKi:  96nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataIC50:  0.450nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255524(N4-[(2,2-Difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]...)
Affinity DataIC50:  0.450nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Proteolix

Curated by ChEMBL
LigandPNGBDBM50277781((2S)-2-[(2S)-2-[(5-ethoxy-1,2-oxazol-3-yl)formamid...)
Affinity DataIC50:  5nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Proteolix

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255515(US10828301, Compound R950368 | US9499493, R950368)
Affinity DataIC50:  10.7nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255515(US10828301, Compound R950368 | US9499493, R950368)
Affinity DataIC50:  10.7nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255514(US10828301, Compound R921304 | US9499493, R921304)
Affinity DataIC50:  12.8nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255514(US10828301, Compound R921304 | US9499493, R921304)
Affinity DataIC50:  12.8nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Proteolix

Curated by ChEMBL
LigandPNGBDBM50277889(CARFILZOMIB | CHEMBL451887)
Affinity DataIC50:  14nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProteasome subunit beta type-8(Homo sapiens (Human))
Proteolix

Curated by ChEMBL
LigandPNGBDBM50277779(CHEMBL484003 | N-((S)-3-methoxy-1-((S)-3-methoxy-1...)
Affinity DataIC50:  21nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Proteolix

Curated by ChEMBL
LigandPNGBDBM50277815(3-methoxy-N-((S)-3-methoxy-1-((S)-3-methoxy-1-((S)...)
Affinity DataIC50:  22nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255518((+/-)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-phenox...)
Affinity DataIC50:  24nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471742((+/−)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-...)
Affinity DataIC50:  24nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255508(US10828301, Compound R935302 | US9499493, R935302)
Affinity DataIC50:  26.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255508(US10828301, Compound R935302 | US9499493, R935302)
Affinity DataIC50:  26.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255513(US10828301, Compound R940338 | US9499493, R940338)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255513(US10828301, Compound R940338 | US9499493, R940338)
Affinity DataIC50:  28nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255525(N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...)
Affinity DataIC50:  34.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471768(N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...)
Affinity DataIC50:  34.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Proteolix

Curated by ChEMBL
LigandPNGBDBM50277816(3-methoxy-N-((S)-3-methoxy-1-((S)-3-methoxy-1-((S)...)
Affinity DataIC50:  36nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471741(N4-(1,4-Benzoxazine-3-on-6-yl)-5-fluoro-N2-(3-hydr...)
Affinity DataIC50:  37.8nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255501(US9499493, R908702)
Affinity DataIC50:  37.8nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Proteolix

Curated by ChEMBL
LigandPNGBDBM50277780(5-ethoxy-N-((S)-3-methoxy-1-((S)-3-methoxy-1-((S)-...)
Affinity DataIC50:  41nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255509(US10828301, Compound R935304 | US9499493, R935304)
Affinity DataIC50:  42nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255509(US10828301, Compound R935304 | US9499493, R935304)
Affinity DataIC50:  42nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255488(US10828301, Compound R935191 | US9499493, R935191)
Affinity DataIC50:  45nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255488(US10828301, Compound R935191 | US9499493, R935191)
Affinity DataIC50:  45nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471755(5-Fluoro-N4-(3-hydroxyphenyl)-N2-[1-(methoxycarbon...)
Affinity DataIC50:  45.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255506(US9499493, R935237)
Affinity DataIC50:  45.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255507(US10828301, Compound R935293 | US9499493, R935293)
Affinity DataIC50:  46.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255487(US10828301, Compound R935190 | US9499493, R935190)
Affinity DataIC50:  46.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255507(US10828301, Compound R935293 | US9499493, R935293)
Affinity DataIC50:  46.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255487(US10828301, Compound R935190 | US9499493, R935190)
Affinity DataIC50:  46.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255505(US10828301, Compound R926839 | US9499493, R926839)
Affinity DataIC50:  55nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255505(US10828301, Compound R926839 | US9499493, R926839)
Affinity DataIC50:  55nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255510(US10828301, Compound R935307 | US9499493, R935307)
Affinity DataIC50:  57nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255510(US10828301, Compound R935307 | US9499493, R935307)
Affinity DataIC50:  57nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255485(US10828301, Compound R926816 | US9499493, R926816)
Affinity DataIC50:  61.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255485(US10828301, Compound R926816 | US9499493, R926816)
Affinity DataIC50:  61.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471765(N4-[(2,2-Dimethyl-4H-benzo[1,4]oxazin-3-one)-6-yl]...)
Affinity DataIC50:  62nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255523(N4-[(2,2-Dimethyl-4H-benzo[1,4]oxazin-3-one)-6-yl]...)
Affinity DataIC50:  62nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471772(N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N...)
Affinity DataIC50:  66.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255526(N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N...)
Affinity DataIC50:  66.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255477(US10828301, Compound R926505 | US9499493, R926505)
Affinity DataIC50:  70.3nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255477(US10828301, Compound R926505 | US9499493, R926505)
Affinity DataIC50:  70.3nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255489(US9499493, R935193)
Affinity DataIC50:  75nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM471724(N4-(3,4-Ethylenedioxyphenyl)-5-fluoro-N2-(1-methyl...)
Affinity DataIC50:  75nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Proteolix

Curated by ChEMBL
LigandPNGBDBM50277818(2-Me-5-thiazole-Ser(OMe)-Ser(OMe)-Phe-ketoepoxide ...)
Affinity DataIC50:  82nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM255481(US10828301, Compound R926745 | US9499493, R926745)
Affinity DataIC50:  92.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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