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Found 83 with Last Name = 'takada' and Initial = 'k'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

LigandPNGBDBM719((4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(2R)-2-[...)
Affinity DataKi:  0.00230nM ΔG°:  -69.1kJ/molepH: 6.2 T: 2°CAssay Description:Inhibition constants were determined by a fluorometric assay with the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Lys(DABCYL)-Ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

LigandPNGBDBM579((4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(2R)-2-[...)
Affinity DataKi:  0.00550nM ΔG°:  -66.9kJ/molepH: 6.2 T: 2°CAssay Description:Inhibition constants were determined by a fluorometric assay with the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Lys(DABCYL)-Ar...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

LigandPNGBDBM793((2S)-N-[(2S,3S)-4-[(4R)-4-(tert-butylcarbamoyl)-5,...)
Affinity DataKi:  0.00680nM ΔG°:  -66.3kJ/molepH: 6.2 T: 2°CAssay Description:Inhibition constants were determined by a fluorometric assay with the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Lys(DABCYL)-Ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50478507(Nobiloside)
Affinity DataIC50:  488nMAssay Description:Inhibition of Clostridium perfringens neuraminidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM32628(FTC | Fumitremorgin C)
Affinity DataIC50:  790nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50364112(CHEMBL1950962)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of HMT-G9a using S-adenosylmethionine and biotinylated H3 peptide after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50364111(CHEMBL1950961)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of HMT-G9a using S-adenosylmethionine and biotinylated H3 peptide after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of HMT-G9a using S-adenosylmethionine and biotinylated H3 peptide after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307019(CHEMBL599745 | N-(4-hydroxystyryl)-2-methoxy-3-(4-...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50484453(Shishicrellastatin A)
Affinity DataIC50:  6.79E+3nMAssay Description:Inhibition of bovine cathepsin B after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50484452(Shishicrellastatin B)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of bovine cathepsin B after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM32624(Botryllamide G, 7 | US8470888, Botryllamide G)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32624(Botryllamide G, 7 | US8470888, Botryllamide G)
Affinity DataIC50:  6.90E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50047352(CHEMBL3314610)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307021(3-(3,5-dibromo-4-hydroxyphenyl)-N-(4-hydroxystyryl...)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32617(Botryllamide A, 1 | US8470888, Botryllamide A)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32619(Botryllamide B, 2)
Affinity DataIC50:  1.12E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50047353(CHEMBL3314607)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307018(CHEMBL599744 | N-(4-hydroxystyryl)-2-methoxy-3-phe...)
Affinity DataIC50:  1.54E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32621(Botryllamide D, 4)
Affinity DataIC50:  1.64E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32620(Botryllamide C, 3 | US8470888, Botryllamide D)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32623(Botryllamide F, 6 | US8470888, Botryllamide F)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32623(Botryllamide F, 6 | US8470888, Botryllamide F)
Affinity DataIC50:  1.67E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50368642(ACETYLPEPSTATIN)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307020(3-(3,4-dihydroxyphenyl)-N-(4-hydroxystyryl)-2-meth...)
Affinity DataIC50:  1.88E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50428496(CHEMBL2335204)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of sPLA2-IIA (unknown origin)-integrin alphaVbeta3 interaction in human K562 cells pretreated for 30 mins to immobilized sPLA2 before addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307022(4-(2-((Z)-3-(3,5-dibromo-4-hydroxyphenyl)-2-methox...)
Affinity DataIC50:  2.32E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32622(Botryllamide E, 5 | US8470888, Botryllamide I)
Affinity DataIC50:  2.33E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32622(Botryllamide E, 5 | US8470888, Botryllamide I)
Affinity DataIC50:  2.33E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50047355(CHEMBL3314608)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307013(CHEMBL599354 | N-(4-hydroxyphenethyl)-3-(4-hydroxy...)
Affinity DataIC50:  2.52E+4nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50047354(CHEMBL3314609)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM97639(US8470888, Botryllamide J)
Affinity DataIC50:  2.69E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32625(Botryllamide H, 8 | Botryllamide J, 10)
Affinity DataIC50:  2.69E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50047351(CHEBI:7988 | CHEMBL3314611)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32617(Botryllamide A, 1 | US8470888, Botryllamide A)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32617(Botryllamide A, 1 | US8470888, Botryllamide A)
Affinity DataIC50:  3.34E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32622(Botryllamide E, 5 | US8470888, Botryllamide I)
Affinity DataIC50:  4.14E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32626(Botryllamide I, 9)
Affinity DataIC50:  4.14E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50364109(CHEMBL1950960)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of HMT-G9a using S-adenosylmethionine and biotinylated H3 peptide after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50364110(CHEMBL1088849)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of HMT-G9a using S-adenosylmethionine and biotinylated H3 peptide after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50428495(CHEMBL2335207)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of sPLA2-IIA (unknown origin)-integrin alphaVbeta3 interaction in human K562 cells pretreated for 30 mins to immobilized sPLA2 before addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50428497(CHEMBL2335203)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibition of sPLA2-IIA (unknown origin)-integrin alphaVbeta3 interaction in human K562 cells pretreated for 30 mins to immobilized sPLA2 before addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307012(3-(4-hydroxyphenyl)-N-(4-hydroxystyryl)-2-methoxyp...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307014(CHEMBL607573 | N-(4-hydroxyphenethyl)-3-(4-hydroxy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307015(3-(4-hydroxyphenyl)-N-(4-hydroxystyryl)acrylamide ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307016(CHEMBL599747 | N-(2-hydroxy-2-(4-hydroxyphenyl)eth...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307017(3-(4-hydroxyphenyl)-2-methoxyacrylic acid | CHEMBL...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307023(3-(4-(benzyloxy)phenyl)-N-(4-hydroxystyryl)-2-meth...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460/MX20 cells assessed as accumulation of ABCG2 substrate pheophorbide-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50364108(CHEMBL1950959)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HMT-G9a using S-adenosylmethionine and biotinylated H3 peptide after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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