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Found 201 with Last Name = 'talbot' and Initial = 'ac'
LigandPNGBDBM50135575((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135589((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135578(4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propion...)
Affinity DataIC50:  0.490nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135579((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-1-(2-hydroxy-et...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135584((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135582((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-2,3-dihyd...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135586((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methylcarbamo...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135591((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135581((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135590((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-1-(3-oxo-...)
Affinity DataIC50:  3.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135588((S)-3-(3,4-Difluoro-phenyl)-N-[(S)-5-(2,3-dihydro-...)
Affinity DataIC50:  4.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135577((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-dimethylcarba...)
Affinity DataIC50:  5.5nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135583((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-carbamoylmeth...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135585((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methyl-2-oxo-...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135587(CHEMBL335994 | {(S)-5-Benzo[1,3]dioxol-5-yl-3-[(S)...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135576((S)-N-[(S)-5-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM628372(3-((1-(3-(1H-pyrrol-1-yl)butanoyl)-4-hydroxypiperi...)
Affinity DataIC50: <50nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM50450959(CHEMBL4210698 | US11795171, Compound I-56)
Affinity DataIC50: <50nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457130(CHEMBL4203456)
Affinity DataIC50:  60nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457141(CHEMBL4215658)
Affinity DataIC50:  100nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135574((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  101nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7 [208-1102](Homo sapiens (Human))
Valo Early Discovery

US Patent
LigandPNGBDBM421629(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7 [208-1102](Homo sapiens (Human))
Valo Early Discovery

US Patent
LigandPNGBDBM472840((R)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7 [208-1102](Homo sapiens (Human))
Valo Early Discovery

US Patent
LigandPNGBDBM421825(N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-y...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7 [208-1102](Homo sapiens (Human))
Valo Early Discovery

US Patent
LigandPNGBDBM421824(7-amino-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidi...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421629(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421823(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421824(7-amino-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidi...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421825(N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-y...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421629(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421823(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421629(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421823(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421824(7-amino-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidi...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421825(N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-y...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421826((R)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM421827((R)-3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7 [208-1102](Homo sapiens (Human))
Valo Early Discovery

US Patent
LigandPNGBDBM421629(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7 [208-1102](Homo sapiens (Human))
Valo Early Discovery

US Patent
LigandPNGBDBM421823(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50: <200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM628396((R)-N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin...)
Affinity DataIC50:  250nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM628397((R)-1-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin...)
Affinity DataIC50:  250nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM628391(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50:  250nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM628340(3-((4-hydroxy-1-(3-(1-methyl-1H-indol-2-yl)benzoyl...)
Affinity DataIC50:  250nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Valo Health

US Patent
LigandPNGBDBM628316(3-((4-Hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)m...)
Affinity DataIC50:  250nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457145(CHEMBL4211224)
Affinity DataIC50:  260nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457140(CHEMBL4211739)
Affinity DataIC50:  370nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457129(CHEMBL4208315)
Affinity DataIC50:  380nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457132(CHEMBL4217059)
Affinity DataIC50:  380nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457133(CHEMBL4206854)
Affinity DataIC50:  420nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457141(CHEMBL4215658)
Affinity DataIC50:  460nMAssay Description:Inhibition of BRD4 in human MV411 cells assessed as reduction in MYC mRNA expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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