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Found 1023 with Last Name = 'tang' and Initial = 'z'
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | US11420968, Example ABT-199 | Venetoclax)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of Bcl-2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataKi:  0.0160nMAssay Description:Binding affinity to Src (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50244142(CHEMBL4086356 | US10533010, Example I-240 | US1120...)
Affinity DataKi: <1nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50304179(CHEMBL4159388)
Affinity DataKi: <1nMAssay Description:Inhibition of His6 tagged MBP fused Mcl-1 (unknown origin) after 0.5 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50510966(CHEMBL4457559)
Affinity DataKi:  2.40nMAssay Description:Inhibition of MCL1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50244142(CHEMBL4086356 | US10533010, Example I-240 | US1120...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50038704(CHEMBL3354882)
Affinity DataKi:  5.30nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50244111(CHEMBL4082389 | US10533010, Example I-39 | US11208...)
Affinity DataKi:  23nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | US11420968, Example ABT-199 | Venetoclax)
Affinity DataKi:  48nMAssay Description:Inhibition of Bcl-xL (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50514200(CHEMBL4446378 | US10703733, Comparative Example 1)
Affinity DataKi:  60nMMore data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50134574(CHEMBL3746042)
Affinity DataKi:  89nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCarbonic anhydrase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50588843(CHEMBL5185054)
Affinity DataKi:  89nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50244111(CHEMBL4082389 | US10533010, Example I-39 | US11208...)
Affinity DataKi:  108nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  120nMAssay Description:Inhibition of FITC-BAK binding to His6 tagged MBP fused recombinant human MCL1 (172 to 327 residues) expressed in Escherichia coli by fluorescence po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50303352(CHEMBL4164057)
Affinity DataKi:  180nMAssay Description:Inhibition of N-terminal 26 residues truncated 5-FAM labelled Bid-BH3 binding to MCL1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50303216(CHEMBL4165406)
Affinity DataKi:  180nMAssay Description:In vitro inhibitory activity against hog plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50303139(CHEMBL4171930)
Affinity DataKi:  320nMAssay Description:Inhibition of N-terminal 26 residues truncated 5-FAM labelled Bid-BH3 binding to MCL1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50303216(CHEMBL4165406)
Affinity DataKi:  320nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50610929(CHEMBL5271820)
Affinity DataKi:  410nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
LigandPNGBDBM50162774(ABT-199 | US11420968, Example ABT-199 | Venetoclax)
Affinity DataKi: >444nMAssay Description:Inhibition of Mcl-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50610928(CHEMBL5280830)
Affinity DataKi:  450nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  450nMMore data for this Ligand-Target Pair
In DepthDetails
TargetBcl-2-like protein 1(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50303216(CHEMBL4165406)
Affinity DataKi:  480nMAssay Description:Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50304178(CHEMBL4164713)
Affinity DataKi:  480nMAssay Description:Displacement of FAM labelled Bid-derived peptide from MCL1 (unknown origin) incubated for 1 min by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM53290(2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynapht...)
Affinity DataKi:  490nMAssay Description:Inhibition of porcine pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi:  550nMAssay Description:Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013839(CHEMBL2030270)
Affinity DataKi:  1.55E+3nMAssay Description:Inhibition of MCL1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50424732(CHEMBL2314209)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50303215(CHEMBL4167501)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of FITC-BAK binding to MCL1 (172 to 327 residues) (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50304178(CHEMBL4164713)
Affinity DataKi:  3.60E+3nMAssay Description:Displacement of FAM labelled Bid-derived peptide from Bcl-2 (unknown origin) incubated for 1 min by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50312869(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CH...)
Affinity DataKi:  7.90E+3nMAssay Description:Binding affinity to Sphk2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50312869(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CH...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity to Sphk1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199337(CHEMBL3962660 | US10131658, Compound 6)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199337(CHEMBL3962660 | US10131658, Compound 6)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199345(CHEMBL3893700 | US10131658, Compound 201)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199345(CHEMBL3893700 | US10131658, Compound 201)
Affinity DataIC50:  0.0631nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50554031(CHEMBL4749110)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of alphavbeta1 integrin (unknown origin) by solid phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50554030(CHEMBL4756339)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of alphavbeta1 integrin (unknown origin) by solid phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50554033(CHEMBL4794201)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of alphavbeta1 integrin (unknown origin) by solid phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50199411(CHEMBL3951678 | US10131658, Compound 87)
Affinity DataIC50:  0.126nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM249934(US10005782, Compound 63 | US9447106, 63 | US955618...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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