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Found 66 with Last Name = 'taweechai' and Initial = 's'
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)
Affinity DataKi:  0.0300nM ΔG°:  -60.1kJ/mole IC50:  1.82E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18788(6-ethyl-5-phenylpyrimidine-2,4-diamine | CHEMBL221...)
Affinity DataKi:  0.0800nM IC50:  1.52E+3nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  0.210nM ΔG°:  -55.2kJ/mole IC50:  180nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18784(5-(3-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  0.310nM ΔG°:  -54.3kJ/mole IC50:  360nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18779(6-ethyl-5-(4-methylphenyl)pyrimidine-2,4-diamine |...)
Affinity DataKi:  0.390nM ΔG°:  -53.7kJ/mole IC50:  140nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18783(5-(3,4-dichlorophenyl)-6-ethylpyrimidine-2,4-diami...)
Affinity DataKi:  0.520nM ΔG°:  -53.0kJ/mole IC50:  70nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18791(5-phenyl-6-(3-phenylpropyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  0.530nM ΔG°:  -52.9kJ/mole IC50:  800nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18784(5-(3-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  0.540nM IC50:  300nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18787(5-(3-chlorophenyl)-6-[2-(3-phenoxypropoxy)ethyl]py...)
Affinity DataKi:  0.630nM ΔG°:  -52.5kJ/mole IC50:  2.27E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18778(CHEMBL22405 | P16 | methyl 4-[2,6-diamino-5-(4-chl...)
Affinity DataKi:  0.690nM ΔG°:  -52.3kJ/mole IC50:  200nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18785(5-(3-chlorophenyl)-6-methylpyrimidine-2,4-diamine ...)
Affinity DataKi:  0.690nM ΔG°:  -52.3kJ/mole IC50:  2.12E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18786(5-(3-chlorophenyl)-6-(3-phenylpropyl)pyrimidine-2,...)
Affinity DataKi:  0.770nM ΔG°:  -52.0kJ/mole IC50:  2.38E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18781(5-(4-bromophenyl)-6-ethylpyrimidine-2,4-diamine | ...)
Affinity DataKi:  0.780nM ΔG°:  -52.0kJ/mole IC50:  90nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18775(5-(4-chlorophenyl)-6-methylpyrimidine-2,4-diamine ...)
Affinity DataKi:  0.780nM ΔG°:  -52.0kJ/mole IC50:  1.95E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18791(5-phenyl-6-(3-phenylpropyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  0.810nM IC50:  2.76E+3nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18790(6-hexyl-5-phenylpyrimidine-2,4-diamine | CHEMBL416...)
Affinity DataKi:  0.900nM IC50:  3.02E+3nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  1.01nM ΔG°:  -51.3kJ/mole IC50:  350nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18783(5-(3,4-dichlorophenyl)-6-ethylpyrimidine-2,4-diami...)
Affinity DataKi:  1.05nM IC50:  1.05E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18782(5-(4-tert-butylphenyl)-6-ethylpyrimidine-2,4-diami...)
Affinity DataKi:  1.14nM ΔG°:  -51.0kJ/mole IC50:  1.76E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18785(5-(3-chlorophenyl)-6-methylpyrimidine-2,4-diamine ...)
Affinity DataKi:  1.19nM IC50:  1.98E+3nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18786(5-(3-chlorophenyl)-6-(3-phenylpropyl)pyrimidine-2,...)
Affinity DataKi:  1.32nM IC50:  1.39E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18776(5-(4-chlorophenyl)-6-(2-methylpropyl)pyrimidine-2,...)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/mole IC50:  220nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18787(5-(3-chlorophenyl)-6-[2-(3-phenoxypropoxy)ethyl]py...)
Affinity DataKi:  1.53nM IC50:  1.42E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18779(6-ethyl-5-(4-methylphenyl)pyrimidine-2,4-diamine |...)
Affinity DataKi:  2.21nM IC50:  1.24E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  3.04nM IC50:  2.00E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18774(5-(4-chlorophenyl)pyrimidine-2,4-diamine | CHEMBL2...)
Affinity DataKi:  3.42nM ΔG°:  -48.3kJ/mole IC50:  1.52E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18789(6-methyl-5-phenylpyrimidine-2,4-diamine | CHEMBL21...)
Affinity DataKi:  4.18nM ΔG°:  -47.8kJ/mole IC50:  1.13E+4nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18777(5-(4-chlorophenyl)-6-nonylpyrimidine-2,4-diamine)
Affinity DataKi:  4.29nM ΔG°:  -47.8kJ/mole IC50:  2.20E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18781(5-(4-bromophenyl)-6-ethylpyrimidine-2,4-diamine | ...)
Affinity DataKi:  6.59nM IC50:  3.01E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18778(CHEMBL22405 | P16 | methyl 4-[2,6-diamino-5-(4-chl...)
Affinity DataKi:  7.43nM IC50: >5.00E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18793(6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50035483(5-Chloro-N*6*-(2,5-dimethoxy-benzyl)-quinazoline-2...)
Affinity DataKi:  10.2nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18789(6-methyl-5-phenylpyrimidine-2,4-diamine | CHEMBL21...)
Affinity DataKi:  22.5nM IC50:  1.29E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18777(5-(4-chlorophenyl)-6-nonylpyrimidine-2,4-diamine)
Affinity DataKi:  24.5nM IC50: >5.00E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18776(5-(4-chlorophenyl)-6-(2-methylpropyl)pyrimidine-2,...)
Affinity DataKi:  28.1nM IC50:  1.82E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  30.8nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18780(6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine ...)
Affinity DataKi:  37.8nM IC50: >5.00E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18782(5-(4-tert-butylphenyl)-6-ethylpyrimidine-2,4-diami...)
Affinity DataKi:  47.5nM IC50: >5.00E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18792(1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)
Affinity DataKi:  55.6nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18775(5-(4-chlorophenyl)-6-methylpyrimidine-2,4-diamine ...)
Affinity DataKi:  63.4nM IC50: >5.00E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering and Biotechnology At Thailand

LigandPNGBDBM18774(5-(4-chlorophenyl)pyrimidine-2,4-diamine | CHEMBL2...)
Affinity DataKi:  1.08E+3nM IC50: >5.00E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18793(6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]...)
Affinity DataKi:  1.46E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50564418(CHEMBL4792349)
Affinity DataKi:  1.95E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50564428(CHEMBL4798400)
Affinity DataKi:  2.11E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50564417(CHEMBL1231612)
Affinity DataKi:  2.36E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50564429(CHEMBL4795771)
Affinity DataKi:  2.37E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50564413(CHEMBL4780298)
Affinity DataKi:  2.37E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50564427(CHEMBL4789322)
Affinity DataKi:  2.37E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50564426(CHEMBL4796933)
Affinity DataKi:  2.52E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50564430(CHEMBL587606 | TCMDC-131671)
Affinity DataKi:  2.91E+4nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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