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Found 222 with Last Name = 'thacher' and Initial = 's'
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153597(CHEMBL3775807)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with substrate for 5 mins followed by NADPH addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153596(CHEMBL3775765)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153598(CHEMBL3775828)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with substrate for 5 mins followed by NADPH addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM4313((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of EGF-dependent proliferation of human and guinea pig keratinocytes; range 7-15 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM4363((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of EGF-dependent proliferation of human and guinea pig keratinocytes; range 7-15 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153595(CHEMBL3775930)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: >5.00E+4nMAssay Description:Time-dependent inhibition of human CYP2C9More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: >5.00E+4nMAssay Description:Time-dependent inhibition of human CYP2D6More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: >5.00E+4nMAssay Description:Time-dependent inhibition of human CYP2C19More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: >5.00E+4nMAssay Description:Time-dependent inhibition of human CYP1A2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: >5.00E+4nMAssay Description:Time-dependent inhibition of human CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with substrate for 5 mins followed by NADPH addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated with substrate for 5 mins followed by NADPH addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated with substrate for 5 mins followed by NADPH addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using ethoxyresorufin as substrate preincubated with substrate for 5 mins followed by NADPH addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: >5.00E+4nMAssay Description:Time-dependent inhibition of human CYP3A4 using testosterone as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated with substrate for 5 mins followed by NADPH addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate preincubated with substrate for 5 mins followed by NADPH addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290178(4-(1-Isopropyl-4,4-dimethyl-2-oxo-1,2,3,4-tetrahyd...)
Affinity DataKd:  18nMAssay Description:Binding affinity of the compound was determined for Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290184(4-(1-Isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataEC50:  17nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor alpha; Not activeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290184(4-(1-Isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataKd:  18nMAssay Description:Binding affinity of the compound was determined for Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290181(4-(1-Heptyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinol...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity of the compound was determined for Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataEC50:  350nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290178(4-(1-Isopropyl-4,4-dimethyl-2-oxo-1,2,3,4-tetrahyd...)
Affinity DataEC50:  20nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290180(4-(4,4-Dimethyl-1,2,3,4-tetrahydro-quinolin-7-ylet...)
Affinity DataEC50:  36nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290185(4-(1-Isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataEC50:  6nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290179(4-(1-Isopropyl-4,4-dimethyl-2-oxo-1,2,3,4-tetrahyd...)
Affinity DataEC50:  4nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290182(4-(4,4-Dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50032219((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)
Affinity DataEC50:  30nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor alphaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290177(4-(4,4-Dimethyl-1,2,3,4-tetrahydro-quinolin-6-ylet...)
Affinity DataEC50:  2.30E+3nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290182(4-(4,4-Dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-...)
Affinity DataEC50:  200nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290180(4-(4,4-Dimethyl-1,2,3,4-tetrahydro-quinolin-7-ylet...)
Affinity DataEC50:  54nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290179(4-(1-Isopropyl-4,4-dimethyl-2-oxo-1,2,3,4-tetrahyd...)
Affinity DataKd:  17nMAssay Description:Binding affinity of the compound was determined for Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataKd:  18nMAssay Description:Binding affinity for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticleMMDB

TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290177(4-(4,4-Dimethyl-1,2,3,4-tetrahydro-quinolin-6-ylet...)
Affinity DataEC50:  170nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290181(4-(1-Heptyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinol...)
Affinity DataEC50:  260nMAssay Description:Transactivation potency of the compound was determined for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataKd:  100nMAssay Description:Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-betaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataEC50:  1.5nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-beta(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50101444((E)-3-Methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,...)
Affinity DataKd:  2.5nMAssay Description:Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-beta(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataEC50:  29nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR betaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataEC50:  4nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-beta(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataKd:  35nMAssay Description:Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-betaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-beta(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50101445((2E,4E)-3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-te...)
Affinity DataEC50:  0.800nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-gamma(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50101445((2E,4E)-3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-te...)
Affinity DataEC50:  0.0800nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM50101444((E)-3-Methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,...)
Affinity DataKd:  1.5nMAssay Description:Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50101446((2E,4E)-3-Methyl-5-[(1R,2R)-2-methyl-2-(5,5,8,8-te...)
Affinity DataKd:  6.20E+3nMAssay Description:Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50101446((2E,4E)-3-Methyl-5-[(1R,2R)-2-methyl-2-(5,5,8,8-te...)
Affinity DataEC50: >500nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50101446((2E,4E)-3-Methyl-5-[(1R,2R)-2-methyl-2-(5,5,8,8-te...)
Affinity DataKd: >10nMAssay Description:Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Allergan

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataKd:  13nMAssay Description:Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
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