TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 870nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 5.10E+3nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.270nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.310nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.690nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.740nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.770nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.820nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.840nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 0.890nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of protein kinase Jak 2More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Tyrosine kinase 2 kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair