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Found 792 with Last Name = 'thomson' and Initial = 'j'
TargetVasopressin V1b receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279757(CHEMBL4166160)
Affinity DataKi: <1nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(RAT)
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]AVP from rat vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279715(CHEMBL4162544)
Affinity DataKi: <1nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279763(CHEMBL4162308)
Affinity DataKi: <1.30nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279744(CHEMBL4165984)
Affinity DataKi: <2nMAssay Description:Inhibition of hog kidney renin at 10e-9 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279743(CHEMBL4170479)
Affinity DataKi:  4nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279773(CHEMBL4173915)
Affinity DataKi:  4nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279720(CHEMBL4177229)
Affinity DataKi:  5nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34012(3-fluorophenylalanine derivative, 21b)
Affinity DataKi:  6nM ΔG°:  -45.4kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50314714((R)-N-(1-(3-fluorophenyl)-3-hydroxypropan-2-yl)ben...)
Affinity DataKi:  6nMAssay Description:Displacement of WFYpSPFLE from human Pin1 catalytic domain after 10-20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279737(CHEMBL4170653)
Affinity DataKi:  6nMAssay Description:Inhibition of HMG-CoA reductase in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279743(CHEMBL4170479)
Affinity DataKi:  7nMAssay Description:Inhibition of hog kidney renin at 10e-9 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279757(CHEMBL4166160)
Affinity DataKi: <8nMAssay Description:Inhibition of Mycobacterium tuberculosis PknA (M1 to A296 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells using [T-33P]ATP as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34011(3-fluorophenylalanine derivative, 21a)
Affinity DataKi:  8nM ΔG°:  -44.7kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279737(CHEMBL4170653)
Affinity DataKi: <8nMAssay Description:Inhibition of Mycobacterium tuberculosis PknA (M1 to A296 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells using [T-33P]ATP as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279759(CHEMBL4172982)
Affinity DataKi: <8nMAssay Description:Inhibition of human plasma renin at 10e-9 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279733(CHEMBL4174082)
Affinity DataKi:  9nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) using HSSPHQ(Sp)EDEEE as substrate by pyruvate kinase-lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279763(CHEMBL4162308)
Affinity DataKi:  9nMAssay Description:Inhibition of Mycobacterium tuberculosis PknA (M1 to A296 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells using [T-33P]ATP as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279744(CHEMBL4165984)
Affinity DataKi:  11nMAssay Description:Inhibition of Mycobacterium tuberculosis PknA (M1 to A296 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells using [T-33P]ATP as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279733(CHEMBL4174082)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant CDK2/cyclin A (unknown origin) using MAHHRSPRKRAKKK as substrate by pyruvate kinase-lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279715(CHEMBL4162544)
Affinity DataKi:  12nMAssay Description:Inhibition of HMG-CoA reductase in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279734(CHEMBL4177445)
Affinity DataKi:  13nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279723(CHEMBL4165949)
Affinity DataKi:  15nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279759(CHEMBL4172982)
Affinity DataKi:  17nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279763(CHEMBL4162308)
Affinity DataKi:  17nMAssay Description:Inhibition of hog kidney renin at 10e-9 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279742(CHEMBL4166840)
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant SRC (unknown origin) using polyE4Y as substrate by pyruvate kinase-lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279743(CHEMBL4170479)
Affinity DataKi:  18nMAssay Description:Inhibition of Mycobacterium tuberculosis PknA (M1 to A296 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells using [T-33P]ATP as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279773(CHEMBL4173915)
Affinity DataKi:  18nMAssay Description:Inhibition of Mycobacterium tuberculosis PknA (M1 to A296 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells using [T-33P]ATP as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143464(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against hepatitis C virus NS3.4A proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50299343((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]AVP from human vasopressin V1a receptor at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279751(CHEMBL4162719)
Affinity DataKi:  22nMAssay Description:Inhibition of Mycobacterium tuberculosis PknA (M1 to A296 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells using [T-33P]ATP as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279733(CHEMBL4174082)
Affinity DataKi:  22nMAssay Description:Inhibition of hog kidney renin at 10e-9 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279736(CHEMBL4162511)
Affinity DataKi:  23nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279748(CHEMBL4170446)
Affinity DataKi:  23nMAssay Description:Inhibition of hog kidney renin at 10e-9 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279751(CHEMBL4162719)
Affinity DataKi:  24nMAssay Description:Inhibition of human plasma renin at 10e-9 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279750(CHEMBL4159344)
Affinity DataKi:  29nMAssay Description:Inhibition of HMG-CoA reductase in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34013(3-methylphenylalanine derivative, 22a)
Affinity DataKi:  32nM ΔG°:  -41.3kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279746(CHEMBL4169382)
Affinity DataKi:  38nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279733(CHEMBL4174082)
Affinity DataKi:  40nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279742(CHEMBL4166840)
Affinity DataKi:  46nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279735(CHEMBL4173877)
Affinity DataKi:  50nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34014(3-methylphenylalanine derivative, 22b)
Affinity DataKi:  57nM ΔG°:  -40.0kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279777(CHEMBL4172772)
Affinity DataKi:  60nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279742(CHEMBL4166840)
Affinity DataKi:  70nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) using HSSPHQ(Sp)EDEEE as substrate by pyruvate kinase-lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279781(CHEMBL4162101)
Affinity DataKi:  72nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM34015(2,3-difluorophenylalanine derivative, 23a)
Affinity DataKi:  78nM ΔG°:  -39.2kJ/molepH: 7.5 T: 2°CAssay Description:The cis/trans conversion of cis-Suc-AEPFpNA peptide by the PPIase led to the cleavage of para nitroaniline by subtilisin which was monitored at 390 n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279802(CHEMBL4159392)
Affinity DataKi:  81nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279793(CHEMBL4174513)
Affinity DataKi:  82nMAssay Description:Inhibition of HMG-CoA reductase in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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