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Found 180 with Last Name = 'tolomeo' and Initial = 'm'
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2 B(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50497567(CHEMBL3337770)
Affinity DataKi:  4.00E+5nMAssay Description:Competitive inhibition of human recombinant ribonucleotide reductase in presence of varying levels of ATP by Dixon plotMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]paroxetine from Serotonin transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universita Di Ferrara

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007730(CHEMBL3233755)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human HDAC-6 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universita Di Ferrara

Curated by ChEMBL
LigandPNGBDBM50273714(CHEMBL446734 | [2-(Imidazol-1-yl)ethyl]-bisphospho...)
Affinity DataIC50:  9.03nMAssay Description:Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166145((3S,6R)-3-[Bis-(4-fluoro-phenyl)-methoxy]-6-methox...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166146((3S,6S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universita Di Ferrara

Curated by ChEMBL
LigandPNGBDBM50273716(CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...)
Affinity DataIC50:  16.1nMAssay Description:Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166135((3S,6S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-6-methox...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universita Di Ferrara

Curated by ChEMBL
LigandPNGBDBM50273717(CHEMBL504429 | [2-(Imidazol-2-yl-thio)ethyl]-bisph...)
Affinity DataIC50:  28.1nMAssay Description:Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human HDAC-6 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007729(CHEMBL3233488)
Affinity DataIC50:  29nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166141((3S,6S)-3-[(4-Chloro-phenyl)-phenyl-methoxy]-6-met...)
Affinity DataIC50:  32nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007730(CHEMBL3233755)
Affinity DataIC50:  33nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007731(CHEMBL3233754)
Affinity DataIC50:  34nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007732(CHEMBL3233752)
Affinity DataIC50:  54nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50:  61nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007733(CHEMBL3233753)
Affinity DataIC50:  68nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007734(CHEMBL3233485)
Affinity DataIC50:  100nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007735(CHEMBL3233486)
Affinity DataIC50:  110nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50:  118nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166147((3S,6R)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl...)
Affinity DataIC50:  140nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007736(CHEMBL3233483)
Affinity DataIC50:  160nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  243nMAssay Description:Inhibition of human HDAC-8 using RHK(Ac)K(Ac) as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  258nMAssay Description:Inhibition of human HDAC-1 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166151((3S,6S)-3-Benzhydryloxy-6-methoxy-8-methyl-8-aza-b...)
Affinity DataIC50:  276nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166145((3S,6R)-3-[Bis-(4-fluoro-phenyl)-methoxy]-6-methox...)
Affinity DataIC50:  280nMAssay Description:Displacement of [3H]paroxetine from Serotonin transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166150((3S,6S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-6-methox...)
Affinity DataIC50:  340nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  344nMAssay Description:Inhibition of human HDAC-7 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  350nMAssay Description:Inhibition of human HDAC-3/NCOR-2 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  362nMAssay Description:Inhibition of human HDAC-11 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  378nMAssay Description:Inhibition of human HDAC-5 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universita Di Ferrara

Curated by ChEMBL
LigandPNGBDBM50273718(CHEMBL457424 | [2-(Purin-9-yl)ethyl]-bisphosphonic...)
Affinity DataIC50:  388nMAssay Description:Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166143((3S,6S)-3-[(4-Chloro-phenyl)-phenyl-methoxy]-6-met...)
Affinity DataIC50:  400nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  456nMAssay Description:Inhibition of human HDAC-10 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  493nMAssay Description:Inhibition of human HDAC-4 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007730(CHEMBL3233755)
Affinity DataIC50:  521nMAssay Description:Inhibition of human HDAC-11 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166144((3S,6S)-3-[(4-Chloro-phenyl)-phenyl-methoxy]-8-met...)
Affinity DataIC50:  600nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant HDAC1 using modified Boc-Lys(Ac)-AMC MAL as substrate after 1 hr by fluorescent activity assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50026643(CHEMBL3335369)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant HDAC1 using modified Boc-Lys(Ac)-AMC MAL as substrate after 1 hr by fluorescent activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universita Di Ferrara

Curated by ChEMBL
LigandPNGBDBM50273799(CHEMBL452354 | [2-(6-Chloro-purin-9-yl)ethyl]-bisp...)
Affinity DataIC50:  883nMAssay Description:Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007730(CHEMBL3233755)
Affinity DataIC50:  886nMAssay Description:Inhibition of human HDAC-10 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50026641(CHEMBL3335367)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant HDAC1 using modified Boc-Lys(Ac)-AMC MAL as substrate after 1 hr by fluorescent activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166136((R)-6-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-a...)
Affinity DataIC50:  900nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  921nMAssay Description:Inhibition of human HDAC-2 using RHKK(Ac) as substrateMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50135180(CHEMBL3746143)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50166140((S)-6-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-a...)
Affinity DataIC50:  1.13E+3nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007737(CHEMBL3233487)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of GM-FTC from Hsp90-alpha (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50026643(CHEMBL3335369)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant HDAC6 using Z-MAL as substrate after 1 hr by fluorescent activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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